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Acremonium Species: New Emerging Fungal Opportunists—In Vitro Antifungal Susceptibilities and Review









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Acremonium Species: New Emerging Fungal Opportunists—In Vitro Antifungal Susceptibilities and Review











J. Guarro




From the Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, and Laboratori de Microbiologia, Hospital Universitari Sant Joan de Reus, Reus, Spain; and Centraalbureau voor Schimmelcultures, Baarn, the Netherlands







Reprints or correspondence: Dr. J. Guarro, Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, 43201 Reus, Spain.





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J. Guarro








W. Gams




From the Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, and Laboratori de Microbiologia, Hospital Universitari Sant Joan de Reus, Reus, Spain; and Centraalbureau voor Schimmelcultures, Baarn, the Netherlands







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W. Gams








I. Pujol




From the Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, and Laboratori de Microbiologia, Hospital Universitari Sant Joan de Reus, Reus, Spain; and Centraalbureau voor Schimmelcultures, Baarn, the Netherlands







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J. Gené




From the Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, and Laboratori de Microbiologia, Hospital Universitari Sant Joan de Reus, Reus, Spain; and Centraalbureau voor Schimmelcultures, Baarn, the Netherlands







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Clinical Infectious Diseases, Volume 25, Issue 5, 1 November 1997, Pages 1222–1229, https://doi.org/10.1086/516098




Published:

01 November 1997




Article history





Received:

21 January 1997



Revision Received:

21 April 1997



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Abstract


We provide an overview of opportunistic fungal infections caused by Acremonium (Cephalosporium) species and discuss the classification of these species as well as the diagnosis and treatment of acremonium infections. We used a microdilution broth method to compare in vitro susceptibilities and minimum inhibitory concentrations and minimum fungicidal concentrations of amphotericin B, miconazole, itraconazole, 5-fluorocytosine, fluconazole, and ketoconazole for 33 clinical and environmental isolates of Acremonium. In general, the isolates tested displayed little susceptibility to the antifungals tested. Fluconazole and 5-fluorocytosine were ineffective in all cases. The efficacy of the remaining drugs was dependent on the strain. Amphotericin B showed the best results.






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