Vernon Benjamin Mountcastle (July 15, 1918 – January 11, 2015) was Professor Emeritus of Neuroscience at Johns Hopkins University. He discovered and characterized the columnar organization of the cerebral cortex in the 1950s. This discovery was a turning point in investigations of the cerebral cortex, as nearly all cortical studies of sensory function after Mountcastle's 1957 paper,^[1] on the somatosensory cortex, used columnar organization as their basis.^{[2][3][4][5][6][7][8]}

Education and early life[edit]

Mountcastle was born in Shelbyville, Kentucky. He was a graduate of Roanoke College in Virginia, where he was a member of the Sigma Chi Fraternity.^[9]

Research and career[edit]

Mountcastle's interest in cognition, specifically perception, led him to guide his laboratory to studies that linked perception and neural responses in the 1960s. Although there were several notable works from his laboratory, the highest profile early paper appeared in 1968,^[10] a study explaining the neural basis of Flutter and vibration by the action of peripheral mechanoreceptors.^[11][12]

In 1978 Mountcastle proposed that all parts of the neocortex operate through a common principle, with the cortical column being the unit of computation.^[13]

Mountcastle's devotion to studies of single unit neural coding evolved through his leadership in the Bard Laboratories of Neurophysiology at the Johns Hopkins School of Medicine, which for many years, was the only institute in the world devoted to this sub-field. Its work is continued today in the Zanvyl Krieger Mind/Brain Institute. Mountcastle died in Baltimore at the age of 96 in January 2015.^[14]

Awards and honours[edit]

Mountcastle was elected to the National Academy of Sciences in 1966. In 1978, he was awarded the Louisa Gross Horwitz Prize from Columbia University together with David Hubel and Torsten Wiesel, both of whom received the Nobel Prize in Physiology or Medicine in 1981. In 1980, he was awarded the Ralph W. Gerard Prize in Neuroscience. In 1981, Mountcastle became a founding member of the World Cultural Council.^[15] In 1983, he was awarded the Albert Lasker Award for Basic Medical Research. He also received the United States National Medal of Science in 1986. In 1998 Mountcastle was awarded the NAS Award in the Neurosciences from the National Academy of Sciences.^[16]

David Hubel in his Nobel Prize acceptance speech said Mountcastle's "discovery of columns in the somatosensory cortex was surely the single most important contribution to the understanding of cerebral cortex since Ramón y Cajal."^[17]

Jeff Hawkins in his book On Intelligence describes Mountcastle's 1978 article, An organizing principle..., as "the rosetta stone of neuroscience".^[18]

References[edit]