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UGT2B10








UGT2B10


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UGT2B10
Protein UGT2B10 PDB 2o6l.png
Identifiers
Aliases
UGT2B10, UDPGT2B10, UDP glucuronosyltransferase family 2 member B10
External IDs MGI: 2140962 HomoloGene: 117389 GeneCards: UGT2B10


















Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]

Chromosome 4 (human)
Genomic location for UGT2B10

Genomic location for UGT2B10

Band 4q13.2 Start 68,815,993 bp[1]
End 68,831,196 bp[1]























RNA expression pattern
PBB GE UGT2B10 211682 x at fs.png
More reference expression data















Orthologs
Species Human Mouse
Entrez


7365


100727
Ensembl


ENSG00000275190
ENSG00000109181


ENSMUSG00000029260
UniProt


P36537


n/a
RefSeq (mRNA)


NM_001290091
NM_001075
NM_001144767


NM_153598
RefSeq (protein)


NP_001066
NP_001138239
NP_001277020


n/a
Location (UCSC) Chr 4: 68.82 – 68.83 Mb Chr 5: 86.89 – 86.91 Mb

PubMed search		 [3] [4]
Wikidata



View/Edit Human View/Edit Mouse

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene.[5][6]





References[edit]





  1. ^ abc ENSG00000109181 GRCh38: Ensembl release 89: ENSG00000275190, ENSG00000109181 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000029260 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  4. ^ "Mouse PubMed Reference:".


  5. ^ Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (Aug 1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily". Biochem Biophys Res Commun. 194 (1): 496–503. doi:10.1006/bbrc.1993.1847. PMID 8333863.


  6. ^ "Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10".




Further reading[edit]


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  • Chen G, Dellinger RW, Gallagher CJ, et al. (2008). "Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines". Pharmacogenet. Genomics. 18 (3): 181–91. doi:10.1097/FPC.0b013e3282f4dbdd. PMID 18300939.


  • Chen G, Blevins-Primeau AS, Dellinger RW, et al. (2007). "Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism". Cancer Res. 67 (19): 9024–9. doi:10.1158/0008-5472.CAN-07-2245. PMID 17909004.


  • Kaivosaari S, Toivonen P, Hesse LM, et al. (2007). "Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10". Mol. Pharmacol. 72 (3): 761–8. doi:10.1124/mol.107.037093. PMID 17576790.


  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.


  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


  • Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID 10748067.


  • Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus". Biochem. J. 338 (2): 489–98. doi:10.1042/0264-6021:3380489. PMC 1220077. PMID 10024527.


  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.


  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

















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