Skip to main content

ECGF1








ECGF1


From Wikipedia, the free encyclopedia

Jump to navigation
Jump to search






























































TYMP
Protein ECGF1 PDB 1uou.png







Available structures
PDB Ortholog search: PDBe RCSB



Identifiers
Aliases
TYMP, thymidine phosphorylase, ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF
External IDs MGI: 1920212 HomoloGene: 1474 GeneCards: TYMP


















Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)[1]

Chromosome 22 (human)
Genomic location for TYMP

Genomic location for TYMP

Band 22q13.33 Start 50,525,752 bp[1]
End 50,530,056 bp[1]























RNA expression pattern

PBB GE ECGF1 204858 s at fs.png

PBB GE ECGF1 205241 at fs.png
More reference expression data















Orthologs
Species Human Mouse
Entrez


1890


72962
Ensembl


ENSG00000025708


ENSMUSG00000022615
UniProt


P19971


Q99N42
RefSeq (mRNA)


NM_001953
NM_001113755
NM_001113756
NM_001257988
NM_001257989


NM_138302
RefSeq (protein)


NP_001107227
NP_001107228
NP_001244917
NP_001244918
NP_001944


NP_612175
Location (UCSC) Chr 22: 50.53 – 50.53 Mb Chr 15: 89.37 – 89.38 Mb

PubMed search		 [3] [4]
Wikidata



View/Edit Human View/Edit Mouse

Thymidine phosphorylase is an enzyme that in humans is encoded by the TYMP gene.[5][6]


Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells.
Because it limits glial cell proliferation, ECGF1 is also known as thymidine phosphorylase and as gliostatin. The ECGF1 gene contains 10 exons spanning more than 4.3 kb. Thymidine phosphorylase activity of ECGF1 in leukocytes from mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients was less than 5 percent of controls, indicating that loss-of-function mutations in thymidine phosphorylase cause MNGIE.[7]




Contents






  • 1 Interactive pathway map


  • 2 References


  • 3 External links


  • 4 Further reading





Interactive pathway map[edit]


Click on genes, proteins and metabolites below to link to respective articles.[§ 1]






[[File:




FluoropyrimidineActivity_WP1601go to article
go to article
go to article
go to pathway article
go to pathway article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to PubChem Compound
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to pathway article
go to pathway article
go to article
go to article
go to article
go to article
go to article
go to WikiPathways
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article



[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]



FluoropyrimidineActivity_WP1601go to article
go to article
go to article
go to pathway article
go to pathway article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to PubChem Compound
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to pathway article
go to pathway article
go to article
go to article
go to article
go to article
go to article
go to WikiPathways
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article




|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]



Fluorouracil (5-FU) Activity edit







  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}





References[edit]





  1. ^ abc GRCh38: Ensembl release 89: ENSG00000025708 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000022615 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:".


  4. ^ "Mouse PubMed Reference:".


  5. ^ Usuki K, Saras J, Waltenberger J, Miyazono K, Pierce G, Thomason A, Heldin CH (Jun 1992). "Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity". Biochem Biophys Res Commun. 184 (3): 1311–6. doi:10.1016/S0006-291X(05)80025-7. PMID 1590793.


  6. ^ Spinazzola A, Marti R, Nishino I, Andreu AL, Naini A, Tadesse S, Pela I, Zammarchi E, Donati MA, Oliver JA, Hirano M (Feb 2002). "Altered thymidine metabolism due to defects of thymidine phosphorylase". J Biol Chem. 277 (6): 4128–33. doi:10.1074/jbc.M111028200. PMID 11733540.


  7. ^ "Entrez Gene: ECGF1 endothelial cell growth factor 1 (platelet-derived)".




External links[edit]


  • GeneReviews/NIH/NCBI/UW entry on Mitochondrial Neurogastrointestinal Encephalopathy Disease (MNGIE)


Further reading[edit]


.mw-parser-output .refbegin{font-size:90%;margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{list-style-type:none;margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>dd{margin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none}.mw-parser-output .refbegin-100{font-size:100%}



  • Yang Q, Yoshimura G, Mori I, et al. (2002). "Thymidine phosphorylase and breast carcinoma". Anticancer Res. 22 (4): 2355–60. PMID 12174926.


  • Asai K, Nakanishi K, Isobe I, et al. (1992). "Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor". J. Biol. Chem. 267 (28): 20311–6. PMID 1400349.


  • Furukawa T, Yoshimura A, Sumizawa T, et al. (1992). "Angiogenic factor". Nature. 356 (6371): 668. doi:10.1038/356668a0. PMID 1570012.


  • Stenman G, Sahlin P, Dumanski JP, et al. (1992). "Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13". Cytogenet. Cell Genet. 59 (1): 22–3. doi:10.1159/000133191. PMID 1733667.


  • Hagiwara K, Stenman G, Honda H, et al. (1991). "Organization and chromosomal localization of the human platelet-derived endothelial cell growth factor gene". Mol. Cell. Biol. 11 (4): 2125–32. PMC 359900. PMID 2005900.


  • Ishikawa F, Miyazono K, Hellman U, et al. (1989). "Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor". Nature. 338 (6216): 557–62. doi:10.1038/338557a0. PMID 2467210.


  • Bardosi A, Creutzfeldt W, DiMauro S, et al. (1987). "Myo-, neuro-, gastrointestinal encephalopathy (MNGIE syndrome) due to partial deficiency of cytochrome-c-oxidase. A new mitochondrial multisystem disorder". Acta Neuropathol. 74 (3): 248–58. doi:10.1007/BF00688189. PMID 2823522.


  • Miyazono K, Okabe T, Urabe A, et al. (1987). "Purification and properties of an endothelial cell growth factor from human platelets". J. Biol. Chem. 262 (9): 4098–103. PMID 3549724.


  • Usuki K, Gonez LJ, Wernstedt C, et al. (1994). "Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells". Biochim. Biophys. Acta. 1222 (3): 411–4. doi:10.1016/0167-4889(94)90049-3. PMID 8038210.


  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


  • Hirano M, Silvestri G, Blake DM, et al. (1994). "Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): clinical, biochemical, and genetic features of an autosomal recessive mitochondrial disorder". Neurology. 44 (4): 721–7. doi:10.1212/wnl.44.4.721. PMID 8164833.


  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.


  • Stevenson DP, Milligan SR, Collins WP (1998). "Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesis". Am. J. Pathol. 152 (6): 1641–6. PMC 1858429. PMID 9626068.


  • Nishino I, Spinazzola A, Hirano M (1999). "Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder". Science. 283 (5402): 689–92. doi:10.1126/science.283.5402.689. PMID 9924029.


  • Asgari MM, Haggerty JG, McNiff JM, et al. (1999). "Expression and localization of thymidine phosphorylase/platelet-derived endothelial cell growth factor in skin and cutaneous tumors". J. Cutan. Pathol. 26 (6): 287–94. doi:10.1111/j.1600-0560.1999.tb01846.x. PMID 10472757.


  • Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.


  • Sivridis E, Giatromanolaki A, Koukourakis MI, et al. (2000). "Thymidine phosphorylase expression in normal and hyperplastic endometrium". J. Clin. Pathol. 53 (9): 704–8. doi:10.1136/jcp.53.9.704. PMC 1731246. PMID 11041061.


  • Komatsu T, Yamazaki H, Shimada N, et al. (2001). "Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver". Clin. Cancer Res. 7 (3): 675–81. PMID 11297264.


  • Kojima H, Shijubo N, Abe S (2002). "Thymidine phosphorylase and vascular endothelial growth factor in patients with Stage I lung adenocarcinoma". Cancer. 94 (4): 1083–93. doi:10.1002/cncr.10352. PMID 11920479.















Retrieved from "https://en.wikipedia.org/w/index.php?title=ECGF1&oldid=798099739"





Navigation menu


























(window.RLQ=window.RLQ||).push(function(){mw.config.set({"wgPageParseReport":{"limitreport":{"cputime":"0.832","walltime":"1.028","ppvisitednodes":{"value":3461,"limit":1000000},"ppgeneratednodes":{"value":0,"limit":1500000},"postexpandincludesize":{"value":235075,"limit":2097152},"templateargumentsize":{"value":76743,"limit":2097152},"expansiondepth":{"value":11,"limit":40},"expensivefunctioncount":{"value":30,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":61229,"limit":5000000},"entityaccesscount":{"value":31,"limit":400},"timingprofile":["100.00% 803.353 1 -total"," 51.60% 414.497 1 Template:Infobox_gene"," 25.35% 203.664 21 Template:Cite_journal"," 22.25% 178.758 1 Template:PBB_Further_reading"," 11.83% 95.003 1 Template:FluoropyrimidineActivity_WP1601"," 8.59% 68.983 1 Template:CSS_image_crop"," 7.56% 60.703 1 Template:Annotated_image"," 7.04% 56.556 2 Template:Reflist"," 5.34% 42.906 5 Template:Navbox"," 3.27% 26.238 1 Template:PDB_Gallery"]},"scribunto":{"limitreport-timeusage":{"value":"0.554","limit":"10.000"},"limitreport-memusage":{"value":6724618,"limit":52428800}},"cachereport":{"origin":"mw1247","timestamp":"20181023230006","ttl":1900800,"transientcontent":false}}});mw.config.set({"wgBackendResponseTime":1128,"wgHostname":"mw1247"});});
-

Popular posts from this blog

Full-time equivalent

Image
Full-time equivalent From Wikipedia, the free encyclopedia Jump to navigation Jump to search Full-time equivalent ( FTE ) or whole time equivalent ( WTE ) is a unit that indicates the workload of an employed person (or student) in a way that makes workloads or class loads comparable [1] across various contexts. FTE is often used to measure a worker's or student's involvement in a project, or to track cost reductions in an organization. An FTE of 1.0 is equivalent to a full-time worker or student, while an FTE of 0.5 signals half of a full work or school load. [2] Contents 1 U.S. Federal Government 2 In education 2.1 Example 3 Notes 4 References U.S. Federal Government [ edit ] In the U.S. Federal Government, FTE is defined by the Government Accountability Office (GAO) as the number of total hours worked divided by the maximum number of compensable hours in a full-time schedule as
Read more

Bicuculline

Image
Bicuculline From Wikipedia, the free encyclopedia Jump to navigation Jump to search Bicuculline Clinical data ATC code none Identifiers IUPAC name (6 R )-​6-​[(5 S )-​6-​methyl-​5,​6,​7,​8-​tetrahydro​[1,3]dioxolo​[4,5- g ]​isoquinolin-​5-​yl]​furo[3,4- e ]​[1,3]​benzodioxol-​8(6 H )-​one CAS Number 485-49-4   Y PubChem CID 10237 IUPHAR/BPS 2312 ChemSpider 9820   Y UNII Y37615DVKC ChEBI CHEBI:3092   N ChEMBL ChEMBL417990   N ECHA InfoCard 100.006.927 Chemical and physical data Formula C 20 H 17 N O 6 Molar mass 367.352 g/mol 3D model (JSmol) Interactive image Melting point 215 °C (419 °F) SMILES O=C1O[C@H](c3c1c2OCOc2cc3)[C@@H]5c4cc6OCOc6cc4CCN5C InChI InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1   Y Key:IYGYMKDQCDOMRE-ZWKOTPCHSA-N
Read more

さくらももこ

Image
さくら ももこ 本名 非公開 [1] 生誕 ( 1965-05-08 ) 1965年5月8日 日本・静岡県清水市 （現・静岡市清水区） 死没 ( 2018-08-15 ) 2018年8月15日（53歳没） 日本・東京都目黒区 国籍 日本 職業 漫画家 エッセイスト 作詞家 活動期間 1984年 - 2018年 ジャンル 少女漫画 青年漫画 児童漫画 代表作 『ちびまる子ちゃん』 『コジコジ』 受賞 1989年：第13回講談社漫画賞少女部門 （『ちびまる子ちゃん』） 1990年：第32回日本レコード大賞 （『おどるポンポコリン』作詞） 公式サイト さくらプロダクション テンプレートを表示 さくら ももこ （1965年5月8日 - 2018年8月15日 [2] ）は、日本の漫画家、エッセイスト、作詞家、脚本家。また、自身の少女時代をモデルとした代表作のコミック『ちびまる子ちゃん』の主人公の名前でもある。静岡県清水市（現・静岡市清水区）出身。血液型はA型。身長159cm。一男の母親。 代表作のコミック『ちびまる子ちゃん』の単行本の売上は累計3000万部を超える。また、エッセイストとしても独特の視点と語り口で人気が高く、初期エッセイ集三部作『もものかんづめ』『さるのこしかけ』『たいのおかしら』はいずれもミリオンセラーを記録。 目次 1 経歴 2 人物・交遊関係 3 主な作品 3.1 漫画 3.2 エッセイ 3.3 作詞 3.4 詩集 3.5 雑誌・ムック本 3.6 翻訳 3.7 絵本、ドラマ脚本他 3.8 ラジオ出演 3.9 その他 4 関係人物 4.1 アシスタント 4.2 さくらももこを演じた人物 5 脚注 5.1 注釈 5.2 出典 6 外部リンク 経歴 年譜形式の経歴は推奨されていません 。人物の伝記は流れのあるまとまった文章で記述し、年譜は補助的な使用にとどめてください。 （ 2018年8月 ） 清水市立（当時）入江小学校
Read more