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UGT2A2








UGT2A2


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UGT2A2
Identifiers
Aliases
UGT2A2, UDP glucuronosyltransferase family 2 member A2
External IDs MGI: 3576095 HomoloGene: 115736 GeneCards: UGT2A2


















Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]

Chromosome 4 (human)
Genomic location for UGT2A2

Genomic location for UGT2A2

Band 4q13.3 Start 69,589,309 bp[1]
End 69,639,642 bp[1]

































Orthologs
Species Human Mouse
Entrez


574537


552899
Ensembl


ENSG00000271271


ENSMUSG00000029268
UniProt


Q9Y4X1


Q6PDD0
RefSeq (mRNA)


NM_001301233
NM_001105677


NM_001024148
RefSeq (protein)





NP_001019319
Location (UCSC) Chr 4: 69.59 – 69.64 Mb Chr 5: 87.46 – 87.48 Mb

PubMed search		 [3] [4]
Wikidata



View/Edit Human View/Edit Mouse

'UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.[5][6]



Function[edit]


The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.[5]



References[edit]





  1. ^ abc GRCh38: Ensembl release 89: ENSG00000271271 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000029268 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  4. ^ "Mouse PubMed Reference:".


  5. ^ ab "Entrez Gene: UDP glucuronosyltransferase 2 family, polypeptide A2".


  6. ^ Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW (October 2005). "Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily". Pharmacogenet. Genomics. 15 (10): 677–85. doi:10.1097/01.fpc.0000173483.13689.56. PMID 16141793.




This article incorporates text from the United States National Library of Medicine, which is in the public domain.












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