Lactose synthase
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| Lactose synthase |
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 Lactose synthase monomer, Bos taurus + alpha-lactalbumin (mouse)
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| Identifiers |
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EC number |
2.4.1.22
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CAS number |
2604493
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| Databases |
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IntEnz |
IntEnz view
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BRENDA |
BRENDA entry
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ExPASy |
NiceZyme view
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KEGG |
KEGG entry
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MetaCyc |
metabolic pathway
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PRIAM |
profile
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PDB structures |
RCSB PDB PDBe PDBsum
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| Search |
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PMC |
articles
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PubMed |
articles
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NCBI |
proteins
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Lactose synthase is an enzyme that generates lactose from glucose and UDP-galactose.
It is classified under EC 2.4.1.22.
It consists of N-acetyllactosamine synthase and alpha-lactalbumin. Alpha-lactalbumin, which is expressed in response to prolactin, increases the affinity of N-acetyllactosamine synthase for its substrate, causing increased production of lactose during lactation.
External links[edit]
Lactose+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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Fructose / Fructolysis
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- Hepatic fructokinase
- Aldolase B
- Triokinase
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Sorbitol |
- Sorbitol dehydrogenase
- Aldose reductase
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Galactose / Galactolysis
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- Galactokinase
Galactose-1-phosphate uridylyltransferase/UDP-glucose 4-epimerase
- Aldose reductase
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Lactose |
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Mannose |
- Mannose phosphate isomerase
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Transferases: glycosyltransferases (EC 2.4)
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2.4.1: Hexosyl- transferases
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Glucosyl- |
Phosphorylase
- Glycogen synthase
- Debranching enzyme
- Branching enzyme
- 1,3-Beta-glucan synthase
- Ceramide glucosyltransferase
- N-glycosyltransferase
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Galactosyl- |
- Lactose synthase
- B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1GALT1)
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Glucuronosyl- |
- UGT1A1
- UGT1A3
- UGT1A4
- UGT1A5
- UGT1A6
- UGT1A7
- UGT1A8
- UGT1A9
- UGT1A10
- UGT2A1
- UGT2A2
- UGT2A3
- UGT2B4
- UGT2B7
- UGT2B10
- UGT2B11
- UGT2B15
- UGT2B17
- UGT2B28
Hyaluronan synthase: HAS1
- HAS2
- HAS3
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Fucosyl- |
- POFUT1
- POFUT2
- FUT1
- FUT2
- FUT3
- FUT4
- FUT5
- FUT6
- FUT7
- FUT8
- FUT9
- FUT10
- FUT11
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Mannosyl- |
Dolichyl-phosphate-mannose-protein mannosyltransferase
- DPM1
- DPM3
- ALG1
- ALG2
- ALG3
- ALG6
- ALG8
- ALG9
- ALG12
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2.4.2: Pentosyl- transferases
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Ribose |
ADP-ribosyltransferase |
NAD+:diphthamide ADP-ribosyltransferase
NAD(P)+:arginine ADP-ribosyltransferase
- Pertussis toxin
- Cholera toxin
- Poly ADP ribose polymerase
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Phosphoribosyltransferase |
- Adenine phosphoribosyltransferase
- Hypoxanthine-guanine phosphoribosyltransferase
- Uracil phosphoribosyltransferase
- Amidophosphoribosyltransferase
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Other |
Purine nucleoside phosphorylase: Thymidine phosphorylase
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Other |
Xylosyltransferase
Arabinosyltransferase
- Indolylacetylinositol arabinosyltransferase
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2.4.99: Sialyl transferases
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- Beta-galactoside alpha-2,6-sialyltransferase
- Monosialoganglioside sialyltransferase
- ST8SIA4
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Enzymes
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Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
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Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
- Enzyme activator
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Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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Types |
EC1 Oxidoreductases (list)
EC2 Transferases (list)
EC3 Hydrolases (list)
EC4 Lyases (list)
EC5 Isomerases (list)
EC6 Ligases (list)
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Categories:
- Biochemistry stubs
- EC 2.4.1
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