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B3GAT2








B3GAT2


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B3GAT2
Protein B3GAT2 PDB 2d0j.png







Available structures
PDB Ortholog search: PDBe RCSB



Identifiers
Aliases
B3GAT2, GLCATS, beta-1,3-glucuronyltransferase 2
External IDs MGI: 2389490 HomoloGene: 50574 GeneCards: B3GAT2


















Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]

Chromosome 6 (human)
Genomic location for B3GAT2

Genomic location for B3GAT2

Band 6q13 Start 70,856,679 bp[1]
End 70,957,038 bp[1]

































Orthologs
Species Human Mouse
Entrez


135152


280645
Ensembl


ENSG00000112309


ENSMUSG00000026156
UniProt


Q9NPZ5


P59270
RefSeq (mRNA)


NM_080742


NM_172124
RefSeq (protein)


NP_542780


NP_742122
Location (UCSC) Chr 6: 70.86 – 70.96 Mb Chr 1: 23.76 – 23.85 Mb

PubMed search		 [3] [4]
Wikidata



View/Edit Human View/Edit Mouse

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 is an enzyme that in humans is encoded by the B3GAT2 gene.[5][6]


The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system.[6]




Contents






  • 1 Use of HNK-1 Antibody for Neural Crest Research


  • 2 References


  • 3 External links


  • 4 Further reading





Use of HNK-1 Antibody for Neural Crest Research[edit]


Antibodies raised against the HNK-1 epitope have played a large role in studies of the neural crest, especially in the avian embryo.[7] The first antibody raised against this epitope was NC-1,[8] which permitted much easier analyses of neural crest migration pathways. In avians, and especially in other vertebrates, the results of HNK-1 staining should be interpreted with caution as the epitope is not unique to the neural crest.



References[edit]





  1. ^ abc GRCh38: Ensembl release 89: ENSG00000112309 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000026156 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  4. ^ "Mouse PubMed Reference:".


  5. ^ Imiya K, Ishizaki T, Seiki T, Saito F, Inazawa J, Oka S, Kawasaki T (Oct 2002). "cDNA cloning, genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope". Gene. 296 (1–2): 29–36. doi:10.1016/S0378-1119(02)00840-5. PMID 12383500.


  6. ^ ab "Entrez Gene: B3GAT2 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)".


  7. ^ Bronner-Fraser M (May 1986). "Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1". Dev. Biol. 115 (1): 44–55. doi:10.1016/0012-1606(86)90226-5. PMID 3516760.


  8. ^ Vincent M, Thiery JP (June 1984). "A cell surface marker for neural crest and placodal cells: further evolution in peripheral and central nervous system". Dev. Biol. 103 (2): 468–81. doi:10.1016/0012-1606(84)90334-8. PMID 6202575.




External links[edit]


  • Human B3GAT2 genome location and B3GAT2 gene details page in the UCSC Genome Browser.


Further reading[edit]


.mw-parser-output .refbegin{font-size:90%;margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{list-style-type:none;margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>dd{margin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none}.mw-parser-output .refbegin-100{font-size:100%}



  • Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.


  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


  • Marcos I, Galán JJ, Borrego S, Antiñolo G (2003). "Cloning, characterization, and chromosome mapping of the human GlcAT-S gene". J. Hum. Genet. 47 (12): 677–80. doi:10.1007/s100380200103. PMID 12522689.


  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.


  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


  • Kakuda S, Oka S, Kawasaki T (2004). "Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in Escherichia coli". Protein Expr. Purif. 35 (1): 111–9. doi:10.1016/j.pep.2003.12.021. PMID 15039073.


  • Kakuda S, Sato Y, Tonoyama Y, et al. (2005). "Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate". Glycobiology. 15 (2): 203–10. doi:10.1093/glycob/cwi001. PMID 15470230.


  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


  • Shiba T, Kakuda S, Ishiguro M, et al. (2006). "Crystal structure of GlcAT-S, a human glucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope". Proteins. 65 (2): 499–508. doi:10.1002/prot.21118. PMID 16897771.

















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