• transferase activity • metal ion binding • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
Cellular component
• integral component of membrane • Golgi apparatus • membrane • Golgi membrane
Biological process
• glycosaminoglycan metabolic process • protein glycosylation • chondroitin sulfate proteoglycan biosynthetic process • chondroitin sulfate metabolic process • carbohydrate metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
135152
280645
Ensembl
ENSG00000112309
ENSMUSG00000026156
UniProt
Q9NPZ5
P59270
RefSeq (mRNA)
NM_080742
NM_172124
RefSeq (protein)
NP_542780
NP_742122
Location (UCSC)
Chr 6: 70.86 – 70.96 Mb
Chr 1: 23.76 – 23.85 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 is an enzyme that in humans is encoded by the B3GAT2 gene.[5][6]
The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system.[6]
Contents
1Use of HNK-1 Antibody for Neural Crest Research
2References
3External links
4Further reading
Use of HNK-1 Antibody for Neural Crest Research[edit]
Antibodies raised against the HNK-1 epitope have played a large role in studies of the neural crest, especially in the avian embryo.[7] The first antibody raised against this epitope was NC-1,[8] which permitted much easier analyses of neural crest migration pathways. In avians, and especially in other vertebrates, the results of HNK-1 staining should be interpreted with caution as the epitope is not unique to the neural crest.
References[edit]
^ abcGRCh38: Ensembl release 89: ENSG00000112309 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026156 - Ensembl, May 2017
^Imiya K, Ishizaki T, Seiki T, Saito F, Inazawa J, Oka S, Kawasaki T (Oct 2002). "cDNA cloning, genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope". Gene. 296 (1–2): 29–36. doi:10.1016/S0378-1119(02)00840-5. PMID 12383500.
^Bronner-Fraser M (May 1986). "Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1". Dev. Biol. 115 (1): 44–55. doi:10.1016/0012-1606(86)90226-5. PMID 3516760.
^Vincent M, Thiery JP (June 1984). "A cell surface marker for neural crest and placodal cells: further evolution in peripheral and central nervous system". Dev. Biol. 103 (2): 468–81. doi:10.1016/0012-1606(84)90334-8. PMID 6202575.
External links[edit]
Human B3GAT2 genome location and B3GAT2 gene details page in the UCSC Genome Browser.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Marcos I, Galán JJ, Borrego S, Antiñolo G (2003). "Cloning, characterization, and chromosome mapping of the human GlcAT-S gene". J. Hum. Genet. 47 (12): 677–80. doi:10.1007/s100380200103. PMID 12522689.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kakuda S, Oka S, Kawasaki T (2004). "Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in Escherichia coli". Protein Expr. Purif. 35 (1): 111–9. doi:10.1016/j.pep.2003.12.021. PMID 15039073.
Kakuda S, Sato Y, Tonoyama Y, et al. (2005). "Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate". Glycobiology. 15 (2): 203–10. doi:10.1093/glycob/cwi001. PMID 15470230.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Shiba T, Kakuda S, Ishiguro M, et al. (2006). "Crystal structure of GlcAT-S, a human glucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope". Proteins. 65 (2): 499–508. doi:10.1002/prot.21118. PMID 16897771.
v
t
e
PDB gallery
@media all and (max-width:720px){.mw-parser-output .mw-module-gallery{display:block!important;float:none!important}.mw-parser-output .mw-module-gallery div{display:inherit!important;float:none!important;width:auto!important}}
Coverage of Google Street View From Wikipedia, the free encyclopedia Jump to navigation Jump to search Countries and dependencies with: mostly full coverage partial coverage full or partial coverage planned (official) full or partial coverage planned (unofficial) views of selected businesses and/or tourist attractions only views of private businesses only no current or planned coverage Google Street View was first introduced in the United States on May 25, 2007, and until November 26, 2008, featured camera icon markers, each representing at least one major city or area (such as a park), and usually the other nearby cities, towns, suburbs, and parks. Many areas that had coverage were represented by icons. Contents 1 Key additions 2 Timeline of introductions 2.1 2007 2.2 2008 2.3 2009 2.4 2010 2.5 2011 2.6 2012 2.7 2013 2.8 2014 2.9 20...
Full-time equivalent From Wikipedia, the free encyclopedia Jump to navigation Jump to search Full-time equivalent ( FTE ) or whole time equivalent ( WTE ) is a unit that indicates the workload of an employed person (or student) in a way that makes workloads or class loads comparable [1] across various contexts. FTE is often used to measure a worker's or student's involvement in a project, or to track cost reductions in an organization. An FTE of 1.0 is equivalent to a full-time worker or student, while an FTE of 0.5 signals half of a full work or school load. [2] Contents 1 U.S. Federal Government 2 In education 2.1 Example 3 Notes 4 References U.S. Federal Government [ edit ] In the U.S. Federal Government, FTE is defined by the Government Accountability Office (GAO) as the number of total hours worked divided by the maximum number of compensable hours in a full-time schedule as...
Surfing From Wikipedia, the free encyclopedia Jump to navigation Jump to search This article is about stand-up ocean surfing. For other uses, see Surfing (disambiguation). "Surfer" redirects here. For other uses, see Surfer (disambiguation). Surfing A surfer at the Cayucos Pier, Cayucos, California Highest governing body World Surf League (WSL) Characteristics Mixed gender Yes, separate competitions Presence Country or region Worldwide Olympic Will debut in 2020 Surfing on the Gold Coast, Queensland, Australia Surfing is a surface water sport in which the wave rider, referred to as a surfer, rides on the forward or deep face of a moving wave, which usually carries the surfer towards the shore. Waves suitable for surfing are primarily found in the ocean, but can also be found in lakes or rivers in the form of a standing wave or tidal bore. However, surfers can also utilize artifi...
Clash Royale CLAN TAG
