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Bicuculline









Bicuculline


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Bicuculline
Bicuculline.svg
Clinical data
ATC code
  • none
Identifiers
CAS Number

  • 485-49-4 ☑Y

PubChem CID
  • 10237
IUPHAR/BPS
  • 2312
ChemSpider

  • 9820 ☑Y
UNII
  • Y37615DVKC
ChEBI

  • CHEBI:3092 ☒N
ChEMBL

  • ChEMBL417990 ☒N
ECHA InfoCard
100.006.927 Edit this at Wikidata
Chemical and physical data
Formula
C20H17NO6
Molar mass 367.352 g/mol
3D model (JSmol)
  • Interactive image
Melting point 215 °C (419 °F)

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Bicuculline is a phthalide-isoquinoline compound that is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts[1] and has been isolated from Dicentra cucullaria, Adlumia fungosa, and several Corydalis species (all in subfamily Fumarioideae, previously known as family Fumariaceae). Since it blocks the inhibitory action of GABA receptors, the action of bicuculline mimics epilepsy. This property is utilized in laboratories across the world in the in vitro study of epilepsy, generally in hippocampal or cortical neurons in prepared brain slices from rodents. This compound is also routinely used to isolate glutamatergic (excitatory amino acid) receptor function.


The action of bicuculline is primarily on the ionotropic GABAA receptors, which are ligand-gated ion channels concerned chiefly with the passing of chloride ions across the cell membrane, thus promoting an inhibitory influence on the target neuron. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.


The half-maximal inhibitory concentration (IC50) of bicuculline on GABAA receptors is 3 μM.


In addition to being a potent GABAA receptor antagonist, bicuculline can be used to block Ca2+-activated potassium channels.[2]


Sensitivity to bicuculline is defined by IUPHAR as a major criterion in the definition of GABAA receptors 



See also[edit]


  • Picrotoxin


References[edit]





  1. ^ Manske, R. H. F. (1932). "The Alkaloids of Fumaraceous Plants. II. Dicentra cucullaria (L.) Bernh". Canadian Journal of Research. 7 (3): 265–269. doi:10.1139/cjr32-078..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  2. ^ Khawaled, R.; Bruening-Wright, A.; Adelman, J. P.; Maylie, J. (1999). "Bicuculline Block of Small-conductance Calcium-activated Potassium Channels". Pflügers Archiv : European Journal of Physiology. 438 (3): 314–321. doi:10.1007/s004240050915. ISSN 0031-6768. PMID 10398861.
















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