WHO Model List of Essential Medicines
WHO Model List of Essential Medicines
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The WHO Model List of Essential Medicines (EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. The list is frequently used by countries to help develop their own local lists of essential medicine.[1] As of 2016, more than 155 countries have created national lists of essential medicines based on the World Health Organization's model list.[2] This includes countries in both the developed and developing world.[1]
The list is divided into core items and complementary items. The core items are deemed to be the most cost effective options for key health problems and are usable with little additional health care resources. The complementary items either require additional infrastructure such as specially trained health care providers or diagnostic equipment or have a lower cost-benefit ratio.[3] About 25% of items are in the complementary list.[4] Some medications are listed as both core and complementary.[5] While most medications on the list are available as generic products, being under patent does not preclude inclusion.[6]
The first list was published in 1977 and included 212 medications.[1][7] The WHO updates the list every two years.[8] The 14th list was published in 2005 and contained 306 medications.[9] In 2015 the 19th edition of the list was published and contains around 410 medications.[8] The 20th edition was published in 2017 and comprises 433 drugs.[10][11] The national lists contain between 334 and 580 medications.[4]
A separate list for children up to 12 years of age, known as the WHO Model List of Essential Medicines for Children (EMLc), was created in 2007 and is in its 6th edition.[8][12] It was created to make sure that the needs of children were systematically considered such as availability of proper formulations.[13][14] Everything in the children's list is also included in the main list.[15] The list and notes are based on the 19th and 20th edition of the main list.[3][10] An α indicates a medicine is only on the complementary list.[3]
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Contents
1 Anaesthetics
1.1 General anaesthetics and oxygen
1.1.1 Inhalational medicines
1.1.2 Injectable medicines
1.2 Local anaesthetics
1.3 Preoperative medication and sedation for short-term procedures
2 Medicines for pain and palliative care
2.1 Nonopioids and nonsteroidal anti-inflammatory drugs (NSAIDs)
2.2 Opioid analgesics
2.3 Medicines for other common symptoms in palliative care
3 Antiallergics and medicines used in anaphylaxis
4 Antidotes and other substances used in poisonings
4.1 Nonspecific
4.2 Specific
5 Anticonvulsive medication
6 Anti-infective medicines
6.1 Antihelminthics
6.1.1 Intestinal antihelminthics
6.1.2 Antifilarials
6.1.3 Antischistosomals and other antinematode medicines
6.2 Antibiotics
6.2.1 Beta Lactam medicines
6.2.2 Other antibacterials
6.2.3 Antileprosy medicines
6.2.4 Antituberculosis medicines
6.3 Antifungal medicines
6.4 Antiviral medicines
6.4.1 Antiherpes medicines
6.4.2 Antiretrovirals
6.4.2.1 Nucleoside/nucleotide reverse transcriptase inhibitors
6.4.2.2 Non-nucleoside reverse transcriptase inhibitors
6.4.2.3 Protease inhibitors
6.4.2.4 Integrase inhibitors
6.4.2.5 Fixed-dose combinations
6.4.2.6 Medicines for prevention of HIV-related opportunistic infections
6.4.2.7 Other antivirals
6.4.3 Antihepatitis medicines
6.4.3.1 Medicines for hepatitis B
6.4.3.2 Medicines for hepatitis C
6.5 Antiprotozoal medicines
6.5.1 Antiamoebic and antigiardiasis medicines
6.5.2 Antileishmaniasis medicines
6.5.3 Antimalarial medicines
6.5.3.1 For curative treatment
6.5.3.2 For prevention
6.5.4 Antipneumocystosis and antitoxoplasmosis medicines
6.5.5 Antitrypanosomal medicines
6.5.5.1 African trypanosomiasis
6.5.5.1.1 1st stage
6.5.5.1.2 2nd stage
6.5.5.2 American trypanosomiasis
7 Antimigraine medicines
7.1 Acute attack
7.2 Prevention
8 Antineoplastic and immunosuppressives
8.1 Immunosuppressive medicines
8.2 Cytotoxic and adjuvant medicines
8.3 Hormones and antihormones
9 Antiparkinsonism medicines
10 Medicines affecting the blood
10.1 Antianaemia medicines
10.2 Medicines affecting coagulation
10.3 Other medicines for haemoglobinopathies
11 Blood products and plasma substitutes of human origin
11.1 Blood and blood components
11.2 Plasma-derived medicines
11.2.1 Human immunoglobulins
11.2.2 Blood coagulation factors
11.3 Plasma substitutes
12 Cardiovascular medicines
12.1 Antianginal medicines
12.2 Antiarrhythmic medicines
12.3 Antihypertensive medicines
12.4 Medicines used in heart failure
12.5 Antithrombotic medicines
12.5.1 Anti-platelet medicines
12.5.2 Thrombolytic medicines
12.6 Lipid-lowering agents
13 Dermatological (topical)
13.1 Antifungal medicines
13.2 Anti-infective medicines
13.3 Anti-inflammatory and antipruritic medicines
13.4 Medicines affecting skin differentiation and proliferation
13.5 Scabicides and pediculicides
14 Diagnostic agents
14.1 Ophthalmic medicines
14.2 Radiocontrast media
15 Disinfectants and antiseptics
15.1 Antiseptics
15.2 Disinfectants
16 Diuretics
17 Gastrointestinal medicines
17.1 Antiulcer medicines
17.2 Antiemetic medicines
17.3 Anti-inflammatory medicines
17.4 Laxatives
17.5 Medicines used in diarrhea
17.5.1 Oral rehydration
17.5.2 Medicines for diarrhea in children
18 Hormones, other endocrine medicines, and contraceptives
18.1 Adrenal hormones and synthetic substitutes
18.2 Androgens
18.3 Contraceptives
18.3.1 Oral hormonal contraceptives
18.3.2 Injectable hormonal contraceptives
18.3.3 Intrauterine devices
18.3.4 Barrier methods
18.3.5 Implantable contraceptives
18.3.6 Intravaginal contraceptives
18.4 Insulins and other medicines used for diabetes
18.5 Ovulation inducers
18.6 Progestogens
18.7 Thyroid hormones and antithyroid medicines
19 Immunologicals
19.1 Diagnostic agents
19.2 Sera and immunoglobulins
19.3 Vaccines
20 Muscle relaxants (peripherally-acting) and cholinesterase inhibitors
21 Eye preparations
21.1 Anti-infective agents
21.2 Anti-inflammatory agents
21.3 Local anesthetics
21.4 Miotics and antiglaucoma medicines
21.5 Mydriatics
21.6 Anti-vascular endothelial growth factor (VEGF)
22 Oxytocics and antioxytocics
22.1 Oxytocics and abortifacients
22.2 Antioxytocics (tocolytics)
23 Peritoneal dialysis solution
24 Medicines for mental and behavioural disorders
24.1 Medicines used in psychotic disorders
24.2 Medicines used in mood disorders
24.2.1 Medicines used in depressive disorders
24.2.2 Medicines used in bipolar disorders
24.3 Medicines for anxiety disorders
24.4 Medicines used for obsessive compulsive disorders
24.5 Medicines for disorders due to psychoactive substance use
25 Medicines acting on the respiratory tract
25.1 Antiasthmatic and medicines for chronic obstructive pulmonary disease
26 Solutions correcting water, electrolyte and acid-base disturbances
26.1 Oral
26.2 Parenteral
26.3 Miscellaneous
27 Vitamins and minerals
28 Ear, nose and throat medicines in children
29 Specific medicines for neonatal care
29.1 Medicines administered to the neonate
29.2 Medicines administered to the mother
30 Medicines for diseases of joints
30.1 Medicines used to treat gout
30.2 Disease-modifying agents used in rheumatoid disorders
30.3 Juvenile joint diseases
31 Notes
32 References
33 Further reading
Anaesthetics[edit]
General anaesthetics and oxygen[edit]
Inhalational medicines[edit]
- Halothane
- Isoflurane
- Nitrous oxide
- Oxygen
Injectable medicines[edit]
- Ketamine
Propofol[note 1]
Local anaesthetics[edit]
- Bupivacaine
- Lidocaine
- Lidocaine/epinephrine
Ephedrineα (not a local anaesthetic, included in this list for prevention of low blood pressure associated with spinal anaesthesia during caesarean section)
Preoperative medication and sedation for short-term procedures[edit]
- Atropine
- Midazolam
- Morphine
Medicines for pain and palliative care[edit]
Nonopioids and nonsteroidal anti-inflammatory drugs (NSAIDs)[edit]
Acetylsalicylic acid (aspirin)- Ibuprofen
Paracetamol[note 2] (acetaminophen)
Opioid analgesics[edit]
- Codeine
- Fentanyl
Morphine[note 3]
Methadoneα
Medicines for other common symptoms in palliative care[edit]
- Amitriptyline
- Cyclizine
- Dexamethasone
- Diazepam
- Docusate sodium
- Fluoxetine
- Haloperidol
- Hyoscine butylbromide
- Hyoscine hydrobromide
- Lactulose
- Loperamide
- Metoclopramide
- Midazolam
- Ondansetron
- Senna
Antiallergics and medicines used in anaphylaxis[edit]
- Dexamethasone
Epinephrine (adrenaline)- Hydrocortisone
Loratadine[note 4]
- Prednisolone
Antidotes and other substances used in poisonings[edit]
Nonspecific[edit]
- Charcoal, activated
Specific[edit]
- Acetylcysteine
- Atropine
- Calcium gluconate
Methylthioninium chloride (methylene blue)- Naloxone
- Penicillamine
- Prussian blue
- Sodium nitrite
- Sodium thiosulfate
Deferoxamineα
Dimercaprolα
Fomepizoleα
Sodium calcium edetateα
Succimerα
Anticonvulsive medication[edit]
- Carbamazepine
- Diazepam
- Lamotrigine
- Lorazepam
Magnesium sulfate[note 5]
- Midazolam
- Phenobarbital
- Phenytoin
Valproic acid (sodium valproate)
Ethosuximideα
Anti-infective medicines[edit]
Antihelminthics[edit]
Intestinal antihelminthics[edit]
- Albendazole
- Ivermectin
- Levamisole
- Mebendazole
- Niclosamide
- Praziquantel
- Pyrantel
Antifilarials[edit]
- Albendazole
- Diethylcarbamazine
- Ivermectin
Antischistosomals and other antinematode medicines[edit]
- Praziquantel
- Triclabendazole
Oxamniquineα
Antibiotics[edit]
Beta Lactam medicines[edit]
- Amoxicillin
Amoxicillin/clavulanic acid (amoxicillin + clavulanic acid)- Ampicillin
- Benzathine benzylpenicillin
- Benzylpenicillin
- Cefalexin
Cefazolin[note 6]
Cefixime[note 7]
Cefotaxime[note 8]
Ceftriaxone[note 9]
- Cloxacillin
Phenoxymethylpenicillin (penicillin V)- Piperacillin/tazobactam
Procaine benzylpenicillin[note 10]
Ceftazidimeα
Meropenemα
Aztreonamα
Imipenem/cilastatinα[note 11]
Other antibacterials[edit]
- Amikacin
Azithromycin[note 12]
- Chloramphenicol
- Ciprofloxacin
Clarithromycin[note 13]
- Clindamycin
- Doxycycline
- Gentamicin
- Metronidazole
- Nitrofurantoin
- Spectinomycin
- Trimethoprim/sulfamethoxazole
- Vancomycin
Antileprosy medicines[edit]
- Clofazimine
- Dapsone
- Rifampicin
Antituberculosis medicines[edit]
- Ethambutol
Ethambutol/isoniazid (ethambutol + isoniazid)
Ethambutol/isoniazid/pyrazinamide/rifampicin (ethambutol + isoniazid + pyrazinamide + rifampicin)
Ethambutol/isoniazid/rifampicin (ethambutol + isoniazid + rifampicin)- Isoniazid
Isoniazid/pyrazinamide/rifampicin (isoniazid + pyrazinamide + rifampicin)
Isoniazid/rifampicin (isoniazid + rifampicin)- Pyrazinamide
Rifabutin[note 14]
- Rifampicin
Rifapentine[note 15]
Amikacinα
Bedaquilineα
Capreomycinα
Clofazimineα
Cycloserineα[note 16]
Delamanidα
Ethionamideα[note 17]
Kanamycinα
Levofloxacinα[note 18]
Linezolidα
- Moxifloxacin
p-aminosalicylic acidα
Streptomycinα
Antifungal medicines[edit]
- Amphotericin B
- Clotrimazole
- Fluconazole
- Flucytosine
- Griseofulvin
- Itraconazole
- Nystatin
- Voriconazole
Potassium iodideα
Antiviral medicines[edit]
Antiherpes medicines[edit]
- Aciclovir
Antiretrovirals[edit]
Nucleoside/nucleotide reverse transcriptase inhibitors[edit]
Abacavir (ABC)
Lamivudine (3TC)
Tenofovir disoproxil fumarate (TDF)
Zidovudine (ZDV or AZT)
Non-nucleoside reverse transcriptase inhibitors[edit]
Efavirenz (EGV or EFZ)
Nevirapine (NVP)
Protease inhibitors[edit]
- Atazanavir
- Atazanavir/ritonavir
- Darunavir
Lopinavir/ritonavir (LPV/r)- Ritonavir
Integrase inhibitors[edit]
- Dolutegravir
- Raltegravir
Fixed-dose combinations[edit]
- Abacavir/lamivudine
Efavirenz/emtricitabine/tenofovir[note 19]
- Efavirenz/lamivudine/tenofovir
Emtricitabine/tenofovir[note 19]
- Lamivudine/nevirapine/zidovudine
- Lamivudine/zidovudine
[edit]
- Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim
Other antivirals[edit]
Ribavirin[note 20]
- Valganciclovir
Oseltamivirα[note 21]
Antihepatitis medicines[edit]
Medicines for hepatitis B[edit]
Nucleoside/Nucleotide reverse transcriptase inhibitors
- Entecavir
Tenofovir disoproxil fumarate (TDF)
Medicines for hepatitis C[edit]
Nucleotide polymerase inhibitors
- Sofosbuvir
Protease inhibitors
- Simeprevir
NS5A inhibitors
- Daclatasvir
Non-nucleoside polymerase inhibitors
- Dasabuvir
Other antivirals
Ribavirin[note 22]
Pegylated interferon-alpha-2a or pegylated interferon-alpha-2bα[note 23]
Fixed-dose combinations
- Ledipasvir/sofosbuvir
- Ombitasvir/paritaprevir/ritonavir
- Sofosbuvir/velpatasvir
Antiprotozoal medicines[edit]
Antiamoebic and antigiardiasis medicines[edit]
- Diloxanide
- Metronidazole
Antileishmaniasis medicines[edit]
- Amphotericin B
- Miltefosine
- Paromomycin
Sodium stibogluconate or meglumine antimoniate
Antimalarial medicines[edit]
For curative treatment[edit]
Amodiaquine[note 24]
Artemether[note 25]
Artemether/lumefantrine[note 26]
Artesunate[note 27]
Artesunate/amodiaquine[note 28]
- Artesunate/mefloquine
- Artesunate/pyronaridine
Chloroquine[note 29]
- Dihydroartemisinin/piperaquine
Doxycycline[note 30]
Mefloquine[note 24]
Primaquine[note 31]
Quinine[note 32]
Sulfadoxine/pyrimethamine[note 33]
For prevention[edit]
Chloroquine[note 34]
- Doxycycline
- Mefloquine
Proguanil[note 35]
Antipneumocystosis and antitoxoplasmosis medicines[edit]
- Pyrimethamine
- Sulfadiazine
- Sulfamethoxazole/trimethoprim
Pentamidineα
Antitrypanosomal medicines[edit]
African trypanosomiasis[edit]
1st stage[edit]
Pentamidine[note 36]
Suramin sodium[note 37]
2nd stage[edit]
Eflornithine[note 38]
- Melarsoprol
Nifurtimox[note 39]
American trypanosomiasis[edit]
- Benznidazole
- Nifurtimox
Antimigraine medicines[edit]
Acute attack[edit]
Acetylsalicylic acid (Aspirin)- Ibuprofen
- Paracetamol
Prevention[edit]
- Propranolol
Antineoplastic and immunosuppressives[edit]
Immunosuppressive medicines[edit]
Azathioprineα
Ciclosporinα
Cytotoxic and adjuvant medicines[edit]
All-trans retinoic acid (tretinoin)α
Allopurinolα
Asparaginaseα
Bendamustineα
Bleomycinα
Calcium folinateα
Capecitabineα
Carboplatinα
Chlorambucilα
Cisplatinα
Cyclophosphamideα
Cytarabineα
Dacarbazineα
Dactinomycinα
Dasatinibα
Daunorubicinα
Docetaxelα
Doxorubicinα
Etoposideα
Filgrastimα
Fludarabineα
Fluorouracilα
Gemcitabineα
Hydroxycarbamideα
Ifosfamideα
Imatinibα
Irinotecanα
Mercaptopurineα
Mesnaα
Methotrexateα
Nilotinibα
Oxaliplatinα
Paclitaxelα
Procarbazineα
Rituximabα
Thioguanineα
Trastuzumabα
Vinblastineα
Vincristineα
Vinorelbineα
Zoledronic acidα
Hormones and antihormones[edit]
Anastrozoleα
Bicalutamideα
Dexamethasoneα
Hydrocortisoneα
Leuprorelinα
Methylprednisoloneα
Prednisoloneα
Tamoxifenα
Antiparkinsonism medicines[edit]
- Biperiden
Carbidopa/levodopa (levodopa + carbidopa)
Medicines affecting the blood[edit]
Antianaemia medicines[edit]
- Ferrous salt
- Ferrous salt/folic acid
- Folic acid
- Hydroxocobalamin
Erythropoiesis-stimulating agentsα
Medicines affecting coagulation[edit]
- Enoxaparin
- Heparin sodium
- Phytomenadione
- Protamine sulfate
- Tranexamic acid
- Warfarin
Desmopressinα
Other medicines for haemoglobinopathies[edit]
Deferoxamineα[note 40]
Hydroxycarbamideα
Blood products and plasma substitutes of human origin[edit]
Blood and blood components[edit]
- Fresh frozen plasma
- Platelet concentrates
- Packed red blood cells
- Whole blood
Plasma-derived medicines[edit]
Human immunoglobulins[edit]
- Rho(D) immune globulin
- Anti-rabies immunoglobulin
- Anti-tetanus immunoglobulin
Human normal immunoglobulinα
Blood coagulation factors[edit]
Coagulation factor VIIIα
Coagulation factor IXα
Plasma substitutes[edit]
Dextran 70[note 41]
Cardiovascular medicines[edit]
Antianginal medicines[edit]
Bisoprolol[note 42]
- Glyceryl trinitrate
- Isosorbide dinitrate
- Verapamil
Antiarrhythmic medicines[edit]
Bisoprolol[note 42]
- Digoxin
Epinephrine (adrenaline)- Lidocaine
- Verapamil
Amiodaroneα
Antihypertensive medicines[edit]
- Amlodipine
Bisoprolol[note 42]
- Enalapril
Hydralazine[note 43]
- Hydrochlorothiazide
Methyldopa[note 44]
- Losartan
Sodium nitroprussideα
Medicines used in heart failure[edit]
Bisoprolol[note 42]
- Digoxin
- Enalapril
- Furosemide
- Hydrochlorothiazide
- Losartan
- Spironolactone
Dopamineα
Antithrombotic medicines[edit]
Anti-platelet medicines[edit]
Acetylsalicylic acid (aspirin)- Clopidogrel
Thrombolytic medicines[edit]
Streptokinaseα
Lipid-lowering agents[edit]
Simvastatin[note 45]
Dermatological (topical)[edit]
Antifungal medicines[edit]
- Miconazole
- Selenium sulfide
- Sodium thiosulfate
- Terbinafine
Anti-infective medicines[edit]
- Mupirocin
- Potassium permanganate
- Silver sulfadiazine
Anti-inflammatory and antipruritic medicines[edit]
- Betamethasone
- Calamine
- Hydrocortisone
Medicines affecting skin differentiation and proliferation[edit]
- Benzoyl peroxide
- Coal tar
- Fluorouracil
- Podophyllum resin
- Salicylic acid
- Urea
Scabicides and pediculicides[edit]
- Benzyl benzoate
- Permethrin
Diagnostic agents[edit]
Ophthalmic medicines[edit]
- Fluorescein
- Tropicamide
Radiocontrast media[edit]
- Amidotrizoate
- Barium sulfate
- Iohexol
Meglumine iotroxateα
Disinfectants and antiseptics[edit]
Antiseptics[edit]
- Chlorhexidine
- Ethanol
- Povidone iodine
Disinfectants[edit]
- Alcohol based hand rub
- Chlorine base compound
- Chloroxylenol
- Glutaral
Diuretics[edit]
- Amiloride
- Furosemide
- Hydrochlorothiazide
- Mannitol
- Spironolactone
Gastrointestinal medicines[edit]
Pancreatic enzymesα
Antiulcer medicines[edit]
- Omeprazole
- Ranitidine
Antiemetic medicines[edit]
- Dexamethasone
- Metoclopramide
- Ondansetron
Anti-inflammatory medicines[edit]
- Sulfasalazine
Hydrocortisoneα
Laxatives[edit]
- Senna
Medicines used in diarrhea[edit]
Oral rehydration[edit]
- Oral rehydration salts
Medicines for diarrhea in children[edit]
Zinc sulfate[note 46]
Hormones, other endocrine medicines, and contraceptives[edit]
Adrenal hormones and synthetic substitutes[edit]
- Fludrocortisone
- Hydrocortisone
Androgens[edit]
Testosteroneα
Contraceptives[edit]
Oral hormonal contraceptives[edit]
- Ethinylestradiol/levonorgestrel
- Ethinylestradiol/norethisterone
- Levonorgestrel
- Ulipristal
Injectable hormonal contraceptives[edit]
- Estradiol cypionate/medroxyprogesterone acetate
- Medroxyprogesterone acetate
- Norethisterone enantate
Intrauterine devices[edit]
- IUD with copper
- IUD with progestogen
Barrier methods[edit]
- Condoms
- Diaphragms
Implantable contraceptives[edit]
- Etonogestrel—releasing implant
- Levonorgestrel—releasing implant
Intravaginal contraceptives[edit]
- Progesterone vaginal ring
Insulins and other medicines used for diabetes[edit]
Gliclazide[note 47]
- Glucagon
- Insulin injection (soluble)
- Intermediate-acting insulin
- Metformin
Ovulation inducers[edit]
Clomifeneα
Progestogens[edit]
- Medroxyprogesterone acetate
Thyroid hormones and antithyroid medicines[edit]
- Levothyroxine
- Potassium iodide
- Propylthiouracil
Lugol's solutionα
Immunologicals[edit]
Diagnostic agents[edit]
Tuberculin, purified protein derivative (PPD)
Sera and immunoglobulins[edit]
Antivenom immunoglobulin[note 48]
- Diphtheria antitoxin
Vaccines[edit]
- BCG vaccine
Cholera vaccine[note 49]
- Diphtheria vaccine
- Haemophilus influenzae type b vaccine
Hepatitis A vaccine[note 49]
- Hepatitis B vaccine
- HPV vaccine
- Influenza vaccine
Japanese encephalitis vaccine[note 50]
- Measles vaccine
Meningococcal meningitis vaccine[note 49]
- Mumps vaccine
- Pertussis vaccine
- Pneumococcal vaccine
- Poliomyelitis vaccine
Rabies vaccine[note 49]
- Rotavirus vaccine
- Rubella vaccine
- Tetanus vaccine
Tick-borne encephalitis vaccine[note 50]
Typhoid vaccine[note 49]
- Varicella vaccine
Yellow fever vaccine[note 50]
Muscle relaxants (peripherally-acting) and cholinesterase inhibitors[edit]
- Atracurium
- Neostigmine
- Suxamethonium
- Vecuronium
Pyridostigmineα
Eye preparations[edit]
Anti-infective agents[edit]
- Aciclovir
- Azithromycin
- Erythromycin
- Gentamicin
- Natamycin
- Ofloxacin
- Tetracycline
Anti-inflammatory agents[edit]
- Prednisolone
Local anesthetics[edit]
- Tetracaine
Miotics and antiglaucoma medicines[edit]
- Acetazolamide
- Latanoprost
- Pilocarpine
- Timolol
Mydriatics[edit]
Atropine[note 51]
Epinephrine (adrenaline)α
Anti-vascular endothelial growth factor (VEGF)[edit]
Bevacizumabα
Oxytocics and antioxytocics[edit]
Oxytocics and abortifacients[edit]
- Ergometrine
- Misoprostol
- Oxytocin
Mifepristone used with misoprostolα[note 52]
Antioxytocics (tocolytics)[edit]
- Nifedipine
Peritoneal dialysis solution[edit]
Intraperitoneal dialysis solution (of appropriate composition)α
Medicines for mental and behavioural disorders[edit]
Medicines used in psychotic disorders[edit]
- Chlorpromazine
- Fluphenazine
- Haloperidol
- Risperidone
Clozapineα
Medicines used in mood disorders[edit]
Medicines used in depressive disorders[edit]
- Amitriptyline
- Fluoxetine
Medicines used in bipolar disorders[edit]
- Carbamazepine
- Lithium
Valproic acid (sodium valproate)
Medicines for anxiety disorders[edit]
- Diazepam
Medicines used for obsessive compulsive disorders[edit]
- Clomipramine
Medicines for disorders due to psychoactive substance use[edit]
- Nicotine replacement therapy
Methadoneα
Medicines acting on the respiratory tract[edit]
Antiasthmatic and medicines for chronic obstructive pulmonary disease[edit]
- Beclometasone
- Budesonide
- Budesonide/formoterol
Epinephrine (adrenaline)- Ipratropium bromide
Salbutamol (albuterol)
Solutions correcting water, electrolyte and acid-base disturbances[edit]
Oral[edit]
- Oral rehydration salts
- Potassium chloride
Parenteral[edit]
- Glucose
- Glucose with sodium chloride
- Potassium chloride
- Sodium chloride
- Sodium hydrogen carbonate
- Sodium lactate, compound solution
Miscellaneous[edit]
- Water for injection
Vitamins and minerals[edit]
- Ascorbic acid
- Calcium
Cholecalciferol[note 53]
- Ergocalciferol
- Iodine
- Nicotinamide
- Pyridoxine
- Retinol
- Riboflavin
- Sodium fluoride
- Thiamine
Calcium gluconateα
Ear, nose and throat medicines in children[edit]
- Acetic acid
- Budesonide
- Ciprofloxacin
- Xylometazoline
Specific medicines for neonatal care[edit]
Medicines administered to the neonate[edit]
- Caffeine citrate
- Chlorhexidine
Ibuprofenα
- Prostaglandin Eα
- Prostaglandin E1
- Prostaglandin E2
Surfactantα
Medicines administered to the mother[edit]
- Dexamethasone
Medicines for diseases of joints[edit]
Medicines used to treat gout[edit]
- Allopurinol
Disease-modifying agents used in rheumatoid disorders[edit]
- Chloroquine
Azathioprineα
Hydroxychloroquineα
Methotrexateα
Penicillamineα
Sulfasalazineα
Juvenile joint diseases[edit]
Aspirin[note 54]
Notes[edit]
An α indicates the medicine is only on the complementary list. For these items specialized diagnostic or monitoring or specialist training are needed. An item may also be listed as complementary on the basis of higher costs or a less attractive cost-benefit ratio.[3]
^ Thiopental may be used as an alternative depending on local availability and cost.
^ Not recommended for anti‐inflammatory use due to lack of proven benefit to that effect
^ Alternatives limited to hydromorphone and oxycodone
^ There may be a role for sedating antihistamines for limited indications (EMLc).
^ For use in eclampsia and severe pre‐eclampsia and not for other convulsant disorders
^ For surgical prophylaxis
^ Only listed for single‐dose treatment of uncomplicated ano‐genital gonorrhoea
^ Third-generation cephalosporin of choice for use in hospitalized neonates
^ Do not administer with calcium and avoid in infants with hyperbilirubinemia.
^ Procaine benzylpenicillin is not recommended as first-line treatment for neonatal sepsis except in settings with high neonatal mortality, when given by trained health workers in cases where hospital care is not achievable.
^ Only listed for the treatment of life‐threatening hospital‐based infection due to suspected or proven multidrug‐resistant infection
^ Only listed for single‐dose treatment of genital Chlamydia trachomatis and of trachoma
^ Erythromycin may be an alternative. For use in combination regimens for eradication of H. pylori in adults
^ For use only in patients with HIV receiving protease inhibitors
^ For treatment of latent TB infection (LTBI) only
^ Terizidone may be an alternative.
^ Prothionamide may be an alternative.
^ Ofloxacin and moxifloxacin may be alternatives based on availability and programme considerations.
^ ab FTC is an acceptable alternative to 3TC, based on knowledge of the pharmacology, the resistance patterns and clinical trials of antiretrovirals.
^ For the treatment of viral haemorrhagic fevers and in combination with pegylated interferons for the treatment of hepatitis C
^ Potentially severe or complicated illness due to confirmed or suspected influenza virus infection in accordance with WHO treatment guidelines
^ For the treatment of hepatitis C, in combination with peginterferon or direct acting anti-viral medicines
^ To be used in combination with ribavirin
^ ab To be used in combination with artesunate 50 mg
^ For use in the management of severe malaria
^ Not recommended in the first trimester of pregnancy or in children below 5 kg
^ To be used in combination with either amodiaquine, mefloquine or sulfadoxine + pyrimethamine
^ Other combinations that deliver the target doses required such as 153 mg or 200 mg (as hydrochloride) with 50 mg artesunate can be alternatives.
^ For use only for the treatment of P. vivax infection
^ For use only in combination with quinine
^ Only for use to achieve radical cure of P. vivax and P. ovale infections, given for 14 days
^ For use only in the management of severe malaria, and should be used in combination with doxycycline
^ Only in combination with artesunate 50 mg
^ For use only in Central American regions, for use for P. vivax
^ For use only in combination with chloroquine
^ To be used for the treatment of Trypanosoma brucei gambiense infection
^ To be used for the treatment of the initial phase of Trypanosoma brucei rhodesiense infection
^ To be used for the treatment of T. b. gambiense infection
^ Only to be used in combination with eflornithine, for the treatment of T. b. gambiense infection
^ Deferasirox oral form may be an alternative, depending on cost and availability.
^ Polygeline, injectable solution, 3.5% is considered as equivalent.
^ abcd Includes metoprolol and carvedilol as alternatives
^ Hydralazine is listed for use in the acute management of severe pregnancy‐induced hypertension only. Its use in the treatment of essential hypertension is not recommended in view of the availability of more evidence of efficacy and safety of other medicines.
^ Methyldopa is listed for use in the management of pregnancy‐induced hypertension only. Its use in the treatment of essential hypertension is not recommended in view of the availability of more evidence of efficacy and safety of other medicines.
^ For use in high‐risk patients
^ In acute diarrhoea, zinc sulfate should be used as an adjunct to oral rehydration salts
^ Glibenclamide not suitable above 60 years
^ Exact type to be defined locally
^ abcde Recommended for some high-risk populations
^ abc Recommended for certain regions
^ Or homatropine (hydrobromide) or cyclopentolate (hydrochloride)
^ Requires close medical supervision
^ Ergocalciferol can be used as an alternative.
^ For use for rheumatic fever, juvenile arthritis, Kawasaki disease
References[edit]
^ abc "Essential medicines". World Health Organization. Retrieved 19 January 2017..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
^ "The WHO Essential Medicines List (EML): 30th anniversary". World Health Organization. Retrieved 26 June 2016.
^ abcd "19th WHO Model List of Essential Medicines" (pdf). who.int. World Health Organization. April 2015. p. Annex 1. Retrieved 17 January 2017.
^ ab Bansal, D; Purohit, VK (January 2013). "Accessibility and use of essential medicines in health care: Current progress and challenges in India". Journal of Pharmacology & Pharmacotherapeutics. 4 (1): 13–18. doi:10.4103/0976-500X.107642. PMC 3643337. PMID 23662019.
^ "The Selection and Use of Essential Medicines - WHO Technical Report Series, No. 920: 5. Reviews of sections of the Model List: 5.2 Review of core versus complementary listing of medicines". apps.who.int. 2003. Retrieved 6 March 2017.
^ Beall, Reed (2016). "Patents and the WHO Model List of Essential Medicines (18th Edition): Clarifying the Debate on IP and Access" (PDF). WIPO. Retrieved 3 May 2017.
^ Wirtz, VJ; Hogerzeil, HV; Gray, AL; Bigdeli, M; de Joncheere, CP; et al. (28 January 2017). "Essential medicines for universal health coverage". The Lancet. 389 (10067): 403–476. doi:10.1016/S0140-6736(16)31599-9. PMID 27832874.
^ abc "WHO Model Lists of Essential Medicines". World Health Organization. Retrieved 17 January 2017.
^ Prakash, B; Nadig, P; Nayak, A (2016). "Rational Prescription for a Dermatologist". Indian Journal of Dermatology. 61 (1): 32–38. doi:10.4103/0019-5154.174017. PMC 4763692. PMID 26955092.
^ ab "WHO Model List of Essential Medicines 20th List" (PDF). March 2017. Retrieved 8 June 2017.
^ "Essential Medicines List and WHO Model Formulary". World Health Organization. Retrieved 5 May 2018.
^ "WHO Model List of Essential Medicines for Children 6th List" (PDF). who.int. World Health Organization. August 2017. Retrieved 11 April 2018.
^ Rose, K; Anker, JNVd (2010). Guide to Paediatric Drug Development and Clinical Research. Karger Medical and Scientific Publishers. p. 42. ISBN 9783805593625.
^ Seyberth, HW; Rane, A; Schwab, M (2011). Pediatric Clinical Pharmacology. Springer Science & Business Media. p. 358. ISBN 9783642201950.
^ Kalle, H (9 February 2017). "Essential Medicines for Children". Clinical Pharmacology & Therapeutics. 101 (6): 718–720. doi:10.1002/cpt.661. PMID 28182281.
Further reading[edit]
WHO Model Formulary 2008 (PDF). World Health Organization. 2009. ISBN 9789241547659.
The selection and use of essential medicines: Twentieth report of the WHO Expert Committee 2015 (including 19th WHO Model List of Essential Medicines and 5th WHO Model List of Essential Medicines for Children) (PDF). WHO. 2015. ISBN 9789240694941.
Categories:
- World Health Organization essential medicines
- Drug-related lists
- Publications established in 1977
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