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WHO Model List of Essential Medicines


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World map with the words "40 years of the model list of essential medicines 1977–2017"

2017 marked the 40th anniversary of the WHO Model List of Essential Medicines.


The WHO Model List of Essential Medicines (EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. The list is frequently used by countries to help develop their own local lists of essential medicine.[1] As of 2016, more than 155 countries have created national lists of essential medicines based on the World Health Organization's model list.[2] This includes countries in both the developed and developing world.[1]


The list is divided into core items and complementary items. The core items are deemed to be the most cost effective options for key health problems and are usable with little additional health care resources. The complementary items either require additional infrastructure such as specially trained health care providers or diagnostic equipment or have a lower cost-benefit ratio.[3] About 25% of items are in the complementary list.[4] Some medications are listed as both core and complementary.[5] While most medications on the list are available as generic products, being under patent does not preclude inclusion.[6]


The first list was published in 1977 and included 212 medications.[1][7] The WHO updates the list every two years.[8] The 14th list was published in 2005 and contained 306 medications.[9] In 2015 the 19th edition of the list was published and contains around 410 medications.[8] The 20th edition was published in 2017 and comprises 433 drugs.[10][11] The national lists contain between 334 and 580 medications.[4]


A separate list for children up to 12 years of age, known as the WHO Model List of Essential Medicines for Children (EMLc), was created in 2007 and is in its 6th edition.[8][12] It was created to make sure that the needs of children were systematically considered such as availability of proper formulations.[13][14] Everything in the children's list is also included in the main list.[15] The list and notes are based on the 19th and 20th edition of the main list.[3][10] An α indicates a medicine is only on the complementary list.[3]


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Contents






  • 1 Anaesthetics


    • 1.1 General anaesthetics and oxygen


      • 1.1.1 Inhalational medicines


      • 1.1.2 Injectable medicines




    • 1.2 Local anaesthetics


    • 1.3 Preoperative medication and sedation for short-term procedures




  • 2 Medicines for pain and palliative care


    • 2.1 Nonopioids and nonsteroidal anti-inflammatory drugs (NSAIDs)


    • 2.2 Opioid analgesics


    • 2.3 Medicines for other common symptoms in palliative care




  • 3 Antiallergics and medicines used in anaphylaxis


  • 4 Antidotes and other substances used in poisonings


    • 4.1 Nonspecific


    • 4.2 Specific




  • 5 Anticonvulsive medication


  • 6 Anti-infective medicines


    • 6.1 Antihelminthics


      • 6.1.1 Intestinal antihelminthics


      • 6.1.2 Antifilarials


      • 6.1.3 Antischistosomals and other antinematode medicines




    • 6.2 Antibiotics


      • 6.2.1 Beta Lactam medicines


      • 6.2.2 Other antibacterials


      • 6.2.3 Antileprosy medicines


      • 6.2.4 Antituberculosis medicines




    • 6.3 Antifungal medicines


    • 6.4 Antiviral medicines


      • 6.4.1 Antiherpes medicines


      • 6.4.2 Antiretrovirals


        • 6.4.2.1 Nucleoside/nucleotide reverse transcriptase inhibitors


        • 6.4.2.2 Non-nucleoside reverse transcriptase inhibitors


        • 6.4.2.3 Protease inhibitors


        • 6.4.2.4 Integrase inhibitors


        • 6.4.2.5 Fixed-dose combinations


        • 6.4.2.6 Medicines for prevention of HIV-related opportunistic infections


        • 6.4.2.7 Other antivirals




      • 6.4.3 Antihepatitis medicines


        • 6.4.3.1 Medicines for hepatitis B


        • 6.4.3.2 Medicines for hepatitis C






    • 6.5 Antiprotozoal medicines


      • 6.5.1 Antiamoebic and antigiardiasis medicines


      • 6.5.2 Antileishmaniasis medicines


      • 6.5.3 Antimalarial medicines


        • 6.5.3.1 For curative treatment


        • 6.5.3.2 For prevention




      • 6.5.4 Antipneumocystosis and antitoxoplasmosis medicines


      • 6.5.5 Antitrypanosomal medicines


        • 6.5.5.1 African trypanosomiasis


          • 6.5.5.1.1 1st stage


          • 6.5.5.1.2 2nd stage




        • 6.5.5.2 American trypanosomiasis








  • 7 Antimigraine medicines


    • 7.1 Acute attack


    • 7.2 Prevention




  • 8 Antineoplastic and immunosuppressives


    • 8.1 Immunosuppressive medicines


    • 8.2 Cytotoxic and adjuvant medicines


    • 8.3 Hormones and antihormones




  • 9 Antiparkinsonism medicines


  • 10 Medicines affecting the blood


    • 10.1 Antianaemia medicines


    • 10.2 Medicines affecting coagulation


    • 10.3 Other medicines for haemoglobinopathies




  • 11 Blood products and plasma substitutes of human origin


    • 11.1 Blood and blood components


    • 11.2 Plasma-derived medicines


      • 11.2.1 Human immunoglobulins


      • 11.2.2 Blood coagulation factors




    • 11.3 Plasma substitutes




  • 12 Cardiovascular medicines


    • 12.1 Antianginal medicines


    • 12.2 Antiarrhythmic medicines


    • 12.3 Antihypertensive medicines


    • 12.4 Medicines used in heart failure


    • 12.5 Antithrombotic medicines


      • 12.5.1 Anti-platelet medicines


      • 12.5.2 Thrombolytic medicines




    • 12.6 Lipid-lowering agents




  • 13 Dermatological (topical)


    • 13.1 Antifungal medicines


    • 13.2 Anti-infective medicines


    • 13.3 Anti-inflammatory and antipruritic medicines


    • 13.4 Medicines affecting skin differentiation and proliferation


    • 13.5 Scabicides and pediculicides




  • 14 Diagnostic agents


    • 14.1 Ophthalmic medicines


    • 14.2 Radiocontrast media




  • 15 Disinfectants and antiseptics


    • 15.1 Antiseptics


    • 15.2 Disinfectants




  • 16 Diuretics


  • 17 Gastrointestinal medicines


    • 17.1 Antiulcer medicines


    • 17.2 Antiemetic medicines


    • 17.3 Anti-inflammatory medicines


    • 17.4 Laxatives


    • 17.5 Medicines used in diarrhea


      • 17.5.1 Oral rehydration


      • 17.5.2 Medicines for diarrhea in children






  • 18 Hormones, other endocrine medicines, and contraceptives


    • 18.1 Adrenal hormones and synthetic substitutes


    • 18.2 Androgens


    • 18.3 Contraceptives


      • 18.3.1 Oral hormonal contraceptives


      • 18.3.2 Injectable hormonal contraceptives


      • 18.3.3 Intrauterine devices


      • 18.3.4 Barrier methods


      • 18.3.5 Implantable contraceptives


      • 18.3.6 Intravaginal contraceptives




    • 18.4 Insulins and other medicines used for diabetes


    • 18.5 Ovulation inducers


    • 18.6 Progestogens


    • 18.7 Thyroid hormones and antithyroid medicines




  • 19 Immunologicals


    • 19.1 Diagnostic agents


    • 19.2 Sera and immunoglobulins


    • 19.3 Vaccines




  • 20 Muscle relaxants (peripherally-acting) and cholinesterase inhibitors


  • 21 Eye preparations


    • 21.1 Anti-infective agents


    • 21.2 Anti-inflammatory agents


    • 21.3 Local anesthetics


    • 21.4 Miotics and antiglaucoma medicines


    • 21.5 Mydriatics


    • 21.6 Anti-vascular endothelial growth factor (VEGF)




  • 22 Oxytocics and antioxytocics


    • 22.1 Oxytocics and abortifacients


    • 22.2 Antioxytocics (tocolytics)




  • 23 Peritoneal dialysis solution


  • 24 Medicines for mental and behavioural disorders


    • 24.1 Medicines used in psychotic disorders


    • 24.2 Medicines used in mood disorders


      • 24.2.1 Medicines used in depressive disorders


      • 24.2.2 Medicines used in bipolar disorders




    • 24.3 Medicines for anxiety disorders


    • 24.4 Medicines used for obsessive compulsive disorders


    • 24.5 Medicines for disorders due to psychoactive substance use




  • 25 Medicines acting on the respiratory tract


    • 25.1 Antiasthmatic and medicines for chronic obstructive pulmonary disease




  • 26 Solutions correcting water, electrolyte and acid-base disturbances


    • 26.1 Oral


    • 26.2 Parenteral


    • 26.3 Miscellaneous




  • 27 Vitamins and minerals


  • 28 Ear, nose and throat medicines in children


  • 29 Specific medicines for neonatal care


    • 29.1 Medicines administered to the neonate


    • 29.2 Medicines administered to the mother




  • 30 Medicines for diseases of joints


    • 30.1 Medicines used to treat gout


    • 30.2 Disease-modifying agents used in rheumatoid disorders


    • 30.3 Juvenile joint diseases




  • 31 Notes


  • 32 References


  • 33 Further reading





Anaesthetics[edit]



General anaesthetics and oxygen[edit]



Inhalational medicines[edit]



  • Halothane

  • Isoflurane

  • Nitrous oxide

  • Oxygen



Injectable medicines[edit]



  • Ketamine


  • Propofol[note 1]



Local anaesthetics[edit]



  • Bupivacaine

  • Lidocaine

  • Lidocaine/epinephrine


  • Ephedrineα (not a local anaesthetic, included in this list for prevention of low blood pressure associated with spinal anaesthesia during caesarean section)



Preoperative medication and sedation for short-term procedures[edit]



  • Atropine

  • Midazolam

  • Morphine



Medicines for pain and palliative care[edit]



Nonopioids and nonsteroidal anti-inflammatory drugs (NSAIDs)[edit]



A line drawing of a hexagon with two attachments

A skeletal model of the chemical structure of aspirin




  • Acetylsalicylic acid (aspirin)

  • Ibuprofen


  • Paracetamol[note 2] (acetaminophen)



Opioid analgesics[edit]



  • Codeine

  • Fentanyl


  • Morphine[note 3]


  • Methadoneα



Medicines for other common symptoms in palliative care[edit]



  • Amitriptyline

  • Cyclizine

  • Dexamethasone

  • Diazepam

  • Docusate sodium

  • Fluoxetine

  • Haloperidol

  • Hyoscine butylbromide

  • Hyoscine hydrobromide

  • Lactulose

  • Loperamide

  • Metoclopramide

  • Midazolam

  • Ondansetron

  • Senna



Antiallergics and medicines used in anaphylaxis[edit]



  • Dexamethasone


  • Epinephrine (adrenaline)

  • Hydrocortisone


  • Loratadine[note 4]

  • Prednisolone



Antidotes and other substances used in poisonings[edit]



Nonspecific[edit]


  • Charcoal, activated


Specific[edit]



  • Acetylcysteine

  • Atropine

  • Calcium gluconate


  • Methylthioninium chloride (methylene blue)

  • Naloxone

  • Penicillamine

  • Prussian blue

  • Sodium nitrite

  • Sodium thiosulfate


  • Deferoxamineα


  • Dimercaprolα


  • Fomepizoleα


  • Sodium calcium edetateα


  • Succimerα



Anticonvulsive medication[edit]



  • Carbamazepine

  • Diazepam

  • Lamotrigine

  • Lorazepam


  • Magnesium sulfate[note 5]

  • Midazolam

  • Phenobarbital

  • Phenytoin


  • Valproic acid (sodium valproate)


  • Ethosuximideα



Anti-infective medicines[edit]



Antihelminthics[edit]



Intestinal antihelminthics[edit]



A hexagon joined to a polygon with two attachments to this double ringed structure

A skeletal model of the chemical structure of albendazole



  • Albendazole

  • Ivermectin

  • Levamisole

  • Mebendazole

  • Niclosamide

  • Praziquantel

  • Pyrantel



Antifilarials[edit]



  • Albendazole

  • Diethylcarbamazine

  • Ivermectin



Antischistosomals and other antinematode medicines[edit]



  • Praziquantel

  • Triclabendazole


  • Oxamniquineα



Antibiotics[edit]



Beta Lactam medicines[edit]



  • Amoxicillin


  • Amoxicillin/clavulanic acid (amoxicillin + clavulanic acid)

  • Ampicillin

  • Benzathine benzylpenicillin

  • Benzylpenicillin

  • Cefalexin


  • Cefazolin[note 6]


  • Cefixime[note 7]


  • Cefotaxime[note 8]


  • Ceftriaxone[note 9]

  • Cloxacillin


  • Phenoxymethylpenicillin (penicillin V)

  • Piperacillin/tazobactam


  • Procaine benzylpenicillin[note 10]


  • Ceftazidimeα


  • Meropenemα


  • Aztreonamα


  • Imipenem/cilastatinα[note 11]



Other antibacterials[edit]



  • Amikacin


  • Azithromycin[note 12]

  • Chloramphenicol

  • Ciprofloxacin


  • Clarithromycin[note 13]

  • Clindamycin

  • Doxycycline

  • Gentamicin

  • Metronidazole

  • Nitrofurantoin

  • Spectinomycin

  • Trimethoprim/sulfamethoxazole

  • Vancomycin



Antileprosy medicines[edit]



  • Clofazimine

  • Dapsone

  • Rifampicin



Antituberculosis medicines[edit]



A small pile of white crystals

Pure crystals of ethambutol



  • Ethambutol


  • Ethambutol/isoniazid (ethambutol + isoniazid)


  • Ethambutol/isoniazid/pyrazinamide/rifampicin (ethambutol + isoniazid + pyrazinamide + rifampicin)


  • Ethambutol/isoniazid/rifampicin (ethambutol + isoniazid + rifampicin)

  • Isoniazid


  • Isoniazid/pyrazinamide/rifampicin (isoniazid + pyrazinamide + rifampicin)


  • Isoniazid/rifampicin (isoniazid + rifampicin)

  • Pyrazinamide


  • Rifabutin[note 14]

  • Rifampicin


  • Rifapentine[note 15]


  • Amikacinα


  • Bedaquilineα


  • Capreomycinα


  • Clofazimineα


  • Cycloserineα[note 16]


  • Delamanidα


  • Ethionamideα[note 17]


  • Kanamycinα


  • Levofloxacinα[note 18]


  • Linezolidα

  • Moxifloxacin


  • p-aminosalicylic acidα


  • Streptomycinα



Antifungal medicines[edit]



  • Amphotericin B

  • Clotrimazole

  • Fluconazole

  • Flucytosine

  • Griseofulvin

  • Itraconazole

  • Nystatin

  • Voriconazole


  • Potassium iodideα



Antiviral medicines[edit]



Antiherpes medicines[edit]


  • Aciclovir


Antiretrovirals[edit]



Nucleoside/nucleotide reverse transcriptase inhibitors[edit]



  • Abacavir (ABC)


  • Lamivudine (3TC)


  • Tenofovir disoproxil fumarate (TDF)


  • Zidovudine (ZDV or AZT)



Non-nucleoside reverse transcriptase inhibitors[edit]



  • Efavirenz (EGV or EFZ)


  • Nevirapine (NVP)



Protease inhibitors[edit]


Two dark blue capsules with writing on them

Two capsules of atazanavir



  • Atazanavir

  • Atazanavir/ritonavir

  • Darunavir


  • Lopinavir/ritonavir (LPV/r)

  • Ritonavir



Integrase inhibitors[edit]


  • Dolutegravir

  • Raltegravir



Fixed-dose combinations[edit]


  • Abacavir/lamivudine


  • Efavirenz/emtricitabine/tenofovir[note 19]

  • Efavirenz/lamivudine/tenofovir


  • Emtricitabine/tenofovir[note 19]

  • Lamivudine/nevirapine/zidovudine

  • Lamivudine/zidovudine



Medicines for prevention of HIV-related opportunistic infections[edit]

  • Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim


Other antivirals[edit]



  • Ribavirin[note 20]

  • Valganciclovir


  • Oseltamivirα[note 21]



Antihepatitis medicines[edit]



Medicines for hepatitis B[edit]

Nucleoside/Nucleotide reverse transcriptase inhibitors



  • Entecavir


  • Tenofovir disoproxil fumarate (TDF)



Medicines for hepatitis C[edit]

Nucleotide polymerase inhibitors


  • Sofosbuvir

Protease inhibitors


  • Simeprevir

NS5A inhibitors


  • Daclatasvir

Non-nucleoside polymerase inhibitors


  • Dasabuvir

Other antivirals




  • Ribavirin[note 22]


  • Pegylated interferon-alpha-2a or pegylated interferon-alpha-2bα[note 23]


Fixed-dose combinations



  • Ledipasvir/sofosbuvir

  • Ombitasvir/paritaprevir/ritonavir

  • Sofosbuvir/velpatasvir



Antiprotozoal medicines[edit]



Antiamoebic and antigiardiasis medicines[edit]



  • Diloxanide

  • Metronidazole



Antileishmaniasis medicines[edit]



  • Amphotericin B

  • Miltefosine

  • Paromomycin


  • Sodium stibogluconate or meglumine antimoniate



Antimalarial medicines[edit]



For curative treatment[edit]



  • Amodiaquine[note 24]


  • Artemether[note 25]


  • Artemether/lumefantrine[note 26]


  • Artesunate[note 27]


  • Artesunate/amodiaquine[note 28]

  • Artesunate/mefloquine

  • Artesunate/pyronaridine


  • Chloroquine[note 29]

  • Dihydroartemisinin/piperaquine


  • Doxycycline[note 30]


  • Mefloquine[note 24]


  • Primaquine[note 31]


  • Quinine[note 32]


  • Sulfadoxine/pyrimethamine[note 33]



For prevention[edit]



  • Chloroquine[note 34]

  • Doxycycline

  • Mefloquine


  • Proguanil[note 35]



Antipneumocystosis and antitoxoplasmosis medicines[edit]



  • Pyrimethamine

  • Sulfadiazine

  • Sulfamethoxazole/trimethoprim


  • Pentamidineα



Antitrypanosomal medicines[edit]



African trypanosomiasis[edit]



1st stage[edit]




  • Pentamidine[note 36]


  • Suramin sodium[note 37]




2nd stage[edit]




  • Eflornithine[note 38]

  • Melarsoprol


  • Nifurtimox[note 39]



American trypanosomiasis[edit]


  • Benznidazole

  • Nifurtimox



Antimigraine medicines[edit]



Acute attack[edit]




  • Acetylsalicylic acid (Aspirin)

  • Ibuprofen

  • Paracetamol



Prevention[edit]


  • Propranolol


Antineoplastic and immunosuppressives[edit]



Immunosuppressive medicines[edit]




  • Azathioprineα


  • Ciclosporinα



Cytotoxic and adjuvant medicines[edit]




  • All-trans retinoic acid (tretinoin)α


  • Allopurinolα


  • Asparaginaseα


  • Bendamustineα


  • Bleomycinα


  • Calcium folinateα


  • Capecitabineα


  • Carboplatinα


  • Chlorambucilα


  • Cisplatinα


  • Cyclophosphamideα


  • Cytarabineα


  • Dacarbazineα


  • Dactinomycinα


  • Dasatinibα


  • Daunorubicinα


  • Docetaxelα


  • Doxorubicinα


  • Etoposideα


  • Filgrastimα


  • Fludarabineα


  • Fluorouracilα


  • Gemcitabineα


  • Hydroxycarbamideα


  • Ifosfamideα


  • Imatinibα


  • Irinotecanα


  • Mercaptopurineα


  • Mesnaα


  • Methotrexateα


  • Nilotinibα


  • Oxaliplatinα


  • Paclitaxelα


  • Procarbazineα


  • Rituximabα


  • Thioguanineα


  • Trastuzumabα


  • Vinblastineα


  • Vincristineα


  • Vinorelbineα


  • Zoledronic acidα



Hormones and antihormones[edit]




  • Anastrozoleα


  • Bicalutamideα


  • Dexamethasoneα


  • Hydrocortisoneα


  • Leuprorelinα


  • Methylprednisoloneα


  • Prednisoloneα


  • Tamoxifenα



Antiparkinsonism medicines[edit]



  • Biperiden


  • Carbidopa/levodopa (levodopa + carbidopa)



Medicines affecting the blood[edit]



Antianaemia medicines[edit]



  • Ferrous salt

  • Ferrous salt/folic acid

  • Folic acid

  • Hydroxocobalamin


  • Erythropoiesis-stimulating agentsα



Medicines affecting coagulation[edit]



  • Enoxaparin

  • Heparin sodium

  • Phytomenadione

  • Protamine sulfate

  • Tranexamic acid

  • Warfarin


  • Desmopressinα



Other medicines for haemoglobinopathies[edit]




  • Deferoxamineα[note 40]


  • Hydroxycarbamideα



Blood products and plasma substitutes of human origin[edit]



Blood and blood components[edit]



A straw colored liquid inside a clear plastic bag

Bag containing one unit of fresh frozen plasma



  • Fresh frozen plasma

  • Platelet concentrates

  • Packed red blood cells

  • Whole blood



Plasma-derived medicines[edit]



Human immunoglobulins[edit]



  • Rho(D) immune globulin

  • Anti-rabies immunoglobulin

  • Anti-tetanus immunoglobulin


  • Human normal immunoglobulinα



Blood coagulation factors[edit]




  • Coagulation factor VIIIα


  • Coagulation factor IXα



Plasma substitutes[edit]



  • Dextran 70[note 41]


Cardiovascular medicines[edit]



Antianginal medicines[edit]




  • Bisoprolol[note 42]

  • Glyceryl trinitrate

  • Isosorbide dinitrate

  • Verapamil



Antiarrhythmic medicines[edit]




  • Bisoprolol[note 42]

  • Digoxin


  • Epinephrine (adrenaline)

  • Lidocaine

  • Verapamil


  • Amiodaroneα



Antihypertensive medicines[edit]



  • Amlodipine


  • Bisoprolol[note 42]

  • Enalapril


  • Hydralazine[note 43]

  • Hydrochlorothiazide


  • Methyldopa[note 44]

  • Losartan


  • Sodium nitroprussideα



Medicines used in heart failure[edit]




  • Bisoprolol[note 42]

  • Digoxin

  • Enalapril

  • Furosemide

  • Hydrochlorothiazide

  • Losartan

  • Spironolactone


  • Dopamineα



Antithrombotic medicines[edit]



Anti-platelet medicines[edit]




  • Acetylsalicylic acid (aspirin)

  • Clopidogrel



Thrombolytic medicines[edit]



  • Streptokinaseα


Lipid-lowering agents[edit]



  • Simvastatin[note 45]


Dermatological (topical)[edit]



Antifungal medicines[edit]



  • Miconazole

  • Selenium sulfide

  • Sodium thiosulfate

  • Terbinafine



Anti-infective medicines[edit]



  • Mupirocin

  • Potassium permanganate

  • Silver sulfadiazine



Anti-inflammatory and antipruritic medicines[edit]



  • Betamethasone

  • Calamine

  • Hydrocortisone



Medicines affecting skin differentiation and proliferation[edit]



  • Benzoyl peroxide

  • Coal tar

  • Fluorouracil

  • Podophyllum resin

  • Salicylic acid

  • Urea



Scabicides and pediculicides[edit]



  • Benzyl benzoate

  • Permethrin



Diagnostic agents[edit]



Ophthalmic medicines[edit]



  • Fluorescein

  • Tropicamide



Radiocontrast media[edit]



  • Amidotrizoate

  • Barium sulfate

  • Iohexol


  • Meglumine iotroxateα



Disinfectants and antiseptics[edit]



Antiseptics[edit]



  • Chlorhexidine

  • Ethanol

  • Povidone iodine



Disinfectants[edit]



  • Alcohol based hand rub

  • Chlorine base compound

  • Chloroxylenol

  • Glutaral



Diuretics[edit]



  • Amiloride

  • Furosemide

  • Hydrochlorothiazide

  • Mannitol

  • Spironolactone



Gastrointestinal medicines[edit]



  • Pancreatic enzymesα


Antiulcer medicines[edit]



  • Omeprazole

  • Ranitidine



Antiemetic medicines[edit]



  • Dexamethasone

  • Metoclopramide

  • Ondansetron



Anti-inflammatory medicines[edit]



  • Sulfasalazine


  • Hydrocortisoneα



Laxatives[edit]


  • Senna


Medicines used in diarrhea[edit]



Oral rehydration[edit]


  • Oral rehydration salts


Medicines for diarrhea in children[edit]



  • Zinc sulfate[note 46]


Hormones, other endocrine medicines, and contraceptives[edit]



Adrenal hormones and synthetic substitutes[edit]



  • Fludrocortisone

  • Hydrocortisone



Androgens[edit]



  • Testosteroneα


Contraceptives[edit]



Oral hormonal contraceptives[edit]



  • Ethinylestradiol/levonorgestrel

  • Ethinylestradiol/norethisterone

  • Levonorgestrel

  • Ulipristal



Injectable hormonal contraceptives[edit]



  • Estradiol cypionate/medroxyprogesterone acetate

  • Medroxyprogesterone acetate

  • Norethisterone enantate



Intrauterine devices[edit]



  • IUD with copper

  • IUD with progestogen



Barrier methods[edit]



  • Condoms

  • Diaphragms



Implantable contraceptives[edit]



  • Etonogestrel—releasing implant

  • Levonorgestrel—releasing implant



Intravaginal contraceptives[edit]


  • Progesterone vaginal ring


Insulins and other medicines used for diabetes[edit]




  • Gliclazide[note 47]

  • Glucagon

  • Insulin injection (soluble)

  • Intermediate-acting insulin

  • Metformin



Ovulation inducers[edit]



  • Clomifeneα


Progestogens[edit]


  • Medroxyprogesterone acetate


Thyroid hormones and antithyroid medicines[edit]



  • Levothyroxine

  • Potassium iodide

  • Propylthiouracil


  • Lugol's solutionα



Immunologicals[edit]



Diagnostic agents[edit]



  • Tuberculin, purified protein derivative (PPD)


Sera and immunoglobulins[edit]




  • Antivenom immunoglobulin[note 48]

  • Diphtheria antitoxin



Vaccines[edit]



A small vial with writing on it being removed from a cardboard package

A vial of oral cholera vaccine



  • BCG vaccine


  • Cholera vaccine[note 49]

  • Diphtheria vaccine

  • Haemophilus influenzae type b vaccine


  • Hepatitis A vaccine[note 49]

  • Hepatitis B vaccine

  • HPV vaccine

  • Influenza vaccine


  • Japanese encephalitis vaccine[note 50]

  • Measles vaccine


  • Meningococcal meningitis vaccine[note 49]

  • Mumps vaccine

  • Pertussis vaccine

  • Pneumococcal vaccine

  • Poliomyelitis vaccine


  • Rabies vaccine[note 49]

  • Rotavirus vaccine

  • Rubella vaccine

  • Tetanus vaccine


  • Tick-borne encephalitis vaccine[note 50]


  • Typhoid vaccine[note 49]

  • Varicella vaccine


  • Yellow fever vaccine[note 50]



Muscle relaxants (peripherally-acting) and cholinesterase inhibitors[edit]



  • Atracurium

  • Neostigmine

  • Suxamethonium

  • Vecuronium


  • Pyridostigmineα



Eye preparations[edit]



Anti-infective agents[edit]



  • Aciclovir

  • Azithromycin

  • Erythromycin

  • Gentamicin

  • Natamycin

  • Ofloxacin

  • Tetracycline



Anti-inflammatory agents[edit]


  • Prednisolone


Local anesthetics[edit]


  • Tetracaine


Miotics and antiglaucoma medicines[edit]



  • Acetazolamide

  • Latanoprost

  • Pilocarpine

  • Timolol



Mydriatics[edit]




  • Atropine[note 51]


  • Epinephrine (adrenaline)α



Anti-vascular endothelial growth factor (VEGF)[edit]



  • Bevacizumabα


Oxytocics and antioxytocics[edit]



Oxytocics and abortifacients[edit]



  • Ergometrine

  • Misoprostol

  • Oxytocin


  • Mifepristone used with misoprostolα[note 52]



Antioxytocics (tocolytics)[edit]


  • Nifedipine


Peritoneal dialysis solution[edit]



  • Intraperitoneal dialysis solution (of appropriate composition)α


Medicines for mental and behavioural disorders[edit]



Medicines used in psychotic disorders[edit]



  • Chlorpromazine

  • Fluphenazine

  • Haloperidol

  • Risperidone


  • Clozapineα



Medicines used in mood disorders[edit]



Medicines used in depressive disorders[edit]



  • Amitriptyline

  • Fluoxetine



Medicines used in bipolar disorders[edit]



  • Carbamazepine

  • Lithium


  • Valproic acid (sodium valproate)



Medicines for anxiety disorders[edit]


  • Diazepam


Medicines used for obsessive compulsive disorders[edit]


  • Clomipramine


Medicines for disorders due to psychoactive substance use[edit]



  • Nicotine replacement therapy


  • Methadoneα



Medicines acting on the respiratory tract[edit]



Antiasthmatic and medicines for chronic obstructive pulmonary disease[edit]



  • Beclometasone

  • Budesonide

  • Budesonide/formoterol


  • Epinephrine (adrenaline)

  • Ipratropium bromide


  • Salbutamol (albuterol)



Solutions correcting water, electrolyte and acid-base disturbances[edit]



Oral[edit]



  • Oral rehydration salts

  • Potassium chloride



Parenteral[edit]



  • Glucose

  • Glucose with sodium chloride

  • Potassium chloride

  • Sodium chloride

  • Sodium hydrogen carbonate

  • Sodium lactate, compound solution



Miscellaneous[edit]


  • Water for injection


Vitamins and minerals[edit]



  • Ascorbic acid

  • Calcium


  • Cholecalciferol[note 53]

  • Ergocalciferol

  • Iodine

  • Nicotinamide

  • Pyridoxine

  • Retinol

  • Riboflavin

  • Sodium fluoride

  • Thiamine


  • Calcium gluconateα



Ear, nose and throat medicines in children[edit]



  • Acetic acid

  • Budesonide

  • Ciprofloxacin

  • Xylometazoline



Specific medicines for neonatal care[edit]



Medicines administered to the neonate[edit]



  • Caffeine citrate

  • Chlorhexidine


  • Ibuprofenα

  • Prostaglandin Eα

    • Prostaglandin E1

    • Prostaglandin E2




  • Surfactantα



Medicines administered to the mother[edit]


  • Dexamethasone


Medicines for diseases of joints[edit]



Medicines used to treat gout[edit]


  • Allopurinol


Disease-modifying agents used in rheumatoid disorders[edit]



  • Chloroquine


  • Azathioprineα


  • Hydroxychloroquineα


  • Methotrexateα


  • Penicillamineα


  • Sulfasalazineα



Juvenile joint diseases[edit]



  • Aspirin[note 54]


Notes[edit]


An α indicates the medicine is only on the complementary list. For these items specialized diagnostic or monitoring or specialist training are needed. An item may also be listed as complementary on the basis of higher costs or a less attractive cost-benefit ratio.[3]





  1. ^ Thiopental may be used as an alternative depending on local availability and cost.


  2. ^ Not recommended for anti‐inflammatory use due to lack of proven benefit to that effect


  3. ^ Alternatives limited to hydromorphone and oxycodone


  4. ^ There may be a role for sedating antihistamines for limited indications (EMLc).


  5. ^ For use in eclampsia and severe pre‐eclampsia and not for other convulsant disorders


  6. ^ For surgical prophylaxis


  7. ^ Only listed for single‐dose treatment of uncomplicated ano‐genital gonorrhoea


  8. ^ Third-generation cephalosporin of choice for use in hospitalized neonates


  9. ^ Do not administer with calcium and avoid in infants with hyperbilirubinemia.


  10. ^ Procaine benzylpenicillin is not recommended as first-line treatment for neonatal sepsis except in settings with high neonatal mortality, when given by trained health workers in cases where hospital care is not achievable.


  11. ^ Only listed for the treatment of life‐threatening hospital‐based infection due to suspected or proven multidrug‐resistant infection


  12. ^ Only listed for single‐dose treatment of genital Chlamydia trachomatis and of trachoma


  13. ^ Erythromycin may be an alternative. For use in combination regimens for eradication of H. pylori in adults


  14. ^ For use only in patients with HIV receiving protease inhibitors


  15. ^ For treatment of latent TB infection (LTBI) only


  16. ^ Terizidone may be an alternative.


  17. ^ Prothionamide may be an alternative.


  18. ^ Ofloxacin and moxifloxacin may be alternatives based on availability and programme considerations.


  19. ^ ab FTC is an acceptable alternative to 3TC, based on knowledge of the pharmacology, the resistance patterns and clinical trials of antiretrovirals.


  20. ^ For the treatment of viral haemorrhagic fevers and in combination with pegylated interferons for the treatment of hepatitis C


  21. ^ Potentially severe or complicated illness due to confirmed or suspected influenza virus infection in accordance with WHO treatment guidelines


  22. ^ For the treatment of hepatitis C, in combination with peginterferon or direct acting anti-viral medicines


  23. ^ To be used in combination with ribavirin


  24. ^ ab To be used in combination with artesunate 50 mg


  25. ^ For use in the management of severe malaria


  26. ^ Not recommended in the first trimester of pregnancy or in children below 5 kg


  27. ^ To be used in combination with either amodiaquine, mefloquine or sulfadoxine + pyrimethamine


  28. ^ Other combinations that deliver the target doses required such as 153 mg or 200 mg (as hydrochloride) with 50 mg artesunate can be alternatives.


  29. ^ For use only for the treatment of P. vivax infection


  30. ^ For use only in combination with quinine


  31. ^ Only for use to achieve radical cure of P. vivax and P. ovale infections, given for 14 days


  32. ^ For use only in the management of severe malaria, and should be used in combination with doxycycline


  33. ^ Only in combination with artesunate 50 mg


  34. ^ For use only in Central American regions, for use for P. vivax


  35. ^ For use only in combination with chloroquine


  36. ^ To be used for the treatment of Trypanosoma brucei gambiense infection


  37. ^ To be used for the treatment of the initial phase of Trypanosoma brucei rhodesiense infection


  38. ^ To be used for the treatment of T. b. gambiense infection


  39. ^ Only to be used in combination with eflornithine, for the treatment of T. b. gambiense infection


  40. ^ Deferasirox oral form may be an alternative, depending on cost and availability.


  41. ^ Polygeline, injectable solution, 3.5% is considered as equivalent.


  42. ^ abcd Includes metoprolol and carvedilol as alternatives


  43. ^ Hydralazine is listed for use in the acute management of severe pregnancy‐induced hypertension only. Its use in the treatment of essential hypertension is not recommended in view of the availability of more evidence of efficacy and safety of other medicines.


  44. ^ Methyldopa is listed for use in the management of pregnancy‐induced hypertension only. Its use in the treatment of essential hypertension is not recommended in view of the availability of more evidence of efficacy and safety of other medicines.


  45. ^ For use in high‐risk patients


  46. ^ In acute diarrhoea, zinc sulfate should be used as an adjunct to oral rehydration salts


  47. ^ Glibenclamide not suitable above 60 years


  48. ^ Exact type to be defined locally


  49. ^ abcde Recommended for some high-risk populations


  50. ^ abc Recommended for certain regions


  51. ^ Or homatropine (hydrobromide) or cyclopentolate (hydrochloride)


  52. ^ Requires close medical supervision


  53. ^ Ergocalciferol can be used as an alternative.


  54. ^ For use for rheumatic fever, juvenile arthritis, Kawasaki disease




References[edit]





  1. ^ abc "Essential medicines". World Health Organization. Retrieved 19 January 2017..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  2. ^ "The WHO Essential Medicines List (EML): 30th anniversary". World Health Organization. Retrieved 26 June 2016.


  3. ^ abcd "19th WHO Model List of Essential Medicines" (pdf). who.int. World Health Organization. April 2015. p. Annex 1. Retrieved 17 January 2017.


  4. ^ ab Bansal, D; Purohit, VK (January 2013). "Accessibility and use of essential medicines in health care: Current progress and challenges in India". Journal of Pharmacology & Pharmacotherapeutics. 4 (1): 13–18. doi:10.4103/0976-500X.107642. PMC 3643337. PMID 23662019.


  5. ^ "The Selection and Use of Essential Medicines - WHO Technical Report Series, No. 920: 5. Reviews of sections of the Model List: 5.2 Review of core versus complementary listing of medicines". apps.who.int. 2003. Retrieved 6 March 2017.


  6. ^ Beall, Reed (2016). "Patents and the WHO Model List of Essential Medicines (18th Edition): Clarifying the Debate on IP and Access" (PDF). WIPO. Retrieved 3 May 2017.


  7. ^ Wirtz, VJ; Hogerzeil, HV; Gray, AL; Bigdeli, M; de Joncheere, CP; et al. (28 January 2017). "Essential medicines for universal health coverage". The Lancet. 389 (10067): 403–476. doi:10.1016/S0140-6736(16)31599-9. PMID 27832874.


  8. ^ abc "WHO Model Lists of Essential Medicines". World Health Organization. Retrieved 17 January 2017.


  9. ^ Prakash, B; Nadig, P; Nayak, A (2016). "Rational Prescription for a Dermatologist". Indian Journal of Dermatology. 61 (1): 32–38. doi:10.4103/0019-5154.174017. PMC 4763692. PMID 26955092.


  10. ^ ab "WHO Model List of Essential Medicines 20th List" (PDF). March 2017. Retrieved 8 June 2017.


  11. ^ "Essential Medicines List and WHO Model Formulary". World Health Organization. Retrieved 5 May 2018.


  12. ^ "WHO Model List of Essential Medicines for Children 6th List" (PDF). who.int. World Health Organization. August 2017. Retrieved 11 April 2018.


  13. ^ Rose, K; Anker, JNVd (2010). Guide to Paediatric Drug Development and Clinical Research. Karger Medical and Scientific Publishers. p. 42. ISBN 9783805593625.


  14. ^ Seyberth, HW; Rane, A; Schwab, M (2011). Pediatric Clinical Pharmacology. Springer Science & Business Media. p. 358. ISBN 9783642201950.


  15. ^ Kalle, H (9 February 2017). "Essential Medicines for Children". Clinical Pharmacology & Therapeutics. 101 (6): 718–720. doi:10.1002/cpt.661. PMID 28182281.




Further reading[edit]




  • WHO Model Formulary 2008 (PDF). World Health Organization. 2009. ISBN 9789241547659.


  • The selection and use of essential medicines: Twentieth report of the WHO Expert Committee 2015 (including 19th WHO Model List of Essential Medicines and 5th WHO Model List of Essential Medicines for Children) (PDF). WHO. 2015. ISBN 9789240694941.












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