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SB-204070









SB-204070


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SB-204070
SB-204070 structure.png
Identifiers
CAS Number
  • 148688-01-1

PubChem CID
  • 121881
IUPHAR/BPS
  • 256
ChemSpider
  • 108731
ChEMBL
  • ChEMBL68131
Chemical and physical data
Formula
C19H27ClN2O4
Molar mass 382.881 g/mol
3D model (JSmol)
  • Interactive image

SB-204070 is a drug which acts as a potent and selective 5-HT4 serotonin receptor antagonist (or weak partial agonist), and is used for research into the function of this receptor subtype.[1][2][3][4][5]



References[edit]





  1. ^ Mialet J; Berque-Bestel I; Sicsic S; Langlois M; Fischmeister R; Lezoualc'h F (October 2000). "Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells". British Journal of Pharmacology. 131 (4): 827–35. doi:10.1038/sj.bjp.0703641. PMC 1572397. PMID 11030734..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  2. ^ Pindon A; van Hecke G; van Gompel P; Lesage AS; Leysen JE; Jurzak M (January 2002). "Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins". Molecular Pharmacology. 61 (1): 85–96. doi:10.1124/mol.61.1.85. PMID 11752209.


  3. ^ Takahashi H; Takada Y; Urano T; Takada A (2002). "5-HT4 receptors in the hippocampus modulate rat locomotor activity". Hippocampus. 12 (3): 304–10. doi:10.1002/hipo.10012. PMID 12099482.


  4. ^ Sakurai-Yamashita Y; Yamashita K; Niwa M; Taniyama K (May 2003). "Involvement of 5-hydroxytryptamine4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia". Brain Research. 973 (1): 92–8. doi:10.1016/S0006-8993(03)02559-9. PMID 12729957.


  5. ^ Smith AJ; Chappell AE; Buret AG; Barrett KE; Dong H (December 2006). "5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury". The FASEB Journal. 20 (14): 2486–95. doi:10.1096/fj.06-6391com. PMID 17142798.














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