Alcoholism: Clinical and Experimental Research
Skip to Main Content
if(true) {
document.getElementById("skipNavigationLink").onclick =function skipElement () {
var element = document.getElementById('article__content');
if(element == null || element == undefined) {
element = document.getElementsByClassName('article__content').item(0);
}
element.setAttribute('tabindex','0');
element.focus();
}
}
- This Journal
- Anywhere
The full text of this article hosted at iucr.org is unavailable due to technical difficulties.
Alcoholism: Clinical and Experimental Research
Volume 31, Issue 1
Sleep Electroencephalographic Spectral Power After Withdrawal from Alcohol in Alcohol‐Dependent Patients
First published: 08 December 2006
Reprint requests: Dr. Bernd Feige, Department of Psychiatry and Psychotherapy, Hauptstraße 5, Freiburg 79104, Germany; Fax: +49‐761‐270‐6619; E‐Mail: Bernd.Feige@gmx.net
This study was supported by the German Ministry for Education and Research (BMBF; FKZ 01 EB 9413).
Abstract
Background: Dysfunctional hyperarousal is suspected to be a neurophysiological determinant of relapse in abstinent alcohol‐dependent patients. In the present study, we used spectral power analysis of the sleep electroencephalographic (EEG) to quantify brain activity during sleep in patients during subacute withdrawal as well as in control subjects. Our hypothesis was that the subgroup of patients who relapsed within the 3 months to follow‐up would exhibit‐increased dysfunctional arousal manifested by higher‐frequency (β) EEG power during sleep.
Methods: Twenty‐six alcohol‐dependent in‐patients were examined with polysomnography over 2 nights 2 to 3 weeks after withdrawal. At the 3‐month clinical follow‐up assessment, 12 of them had relapsed and 14 abstained. The control group consisted of 23 healthy subjects similar to the patients with alcohol dependence in age and gender distribution. Spectral sleep EEG analysis was performed on both nights (adaptation and baseline) of all subjects. Logarithmic artifact‐controlled spectral band power of sleep stage 2 and rapid eye movement (REM) sleep was analyzed for Group, Gender, and Age effects using multiple analyses of covariance. Three groups were compared with the Group factor: relapsers, abstainers, and controls.
Results: Generally, both Group and Age effects were significant for the second, baseline night for the visually scored sleep parameters, while spectral EEG parameters showed significant differences in the adaptation night. In the adaptation night, a significant enhancement in the β2 band (24–32 Hz) was seen in REM sleep in relapsers relative to both abstainers and controls.
Conclusions: The β2 increase could be interpreted as a sign of dysfunctional arousal during REM sleep “unmasked” by the additional stressor of sleep environment adaptation. Its determinants are likely to be both premorbid and drinking history related.
Citing Literature
Number of times cited: 29
Lokesh
Kumar Singh, S Haque Nizamie and Sai Krishna Tikka, Sleep architecture
and EEG power spectra in recently detoxified alcohol dependent patients, Asian Journal of Psychiatry, 10.1016/j.ajp.2017.12.005, 32,
(126-136), (2018).Crossref
Subhajit
Chakravorty, Ninad S. Chaudhary and Kirk J. Brower, Alcohol Dependence
and Its Relationship With Insomnia and Other Sleep Disorders,
Alcoholism: Clinical and Experimental Research, 40,
11, (2271-2282), (2016).Wiley Online Library
Kirk
J. Brower, Assessing and Treating Insomnia Related to Alcohol
Use Disorders, Current
Addiction Reports, 10.1007/s40429-016-0083-1, 3,
1, (98-108), (2016).Crossref
Kirk
J. Brower, Assessment and treatment of insomnia in adult patients
with alcohol use disorders, Alcohol, 49,
4, (417), (2015).Crossref
Bhanu
Prakash Kolla, Terry Schneekloth, Meghna P. Mansukhani, Joanna
M. Biernacka, Daniel Hall‐Flavin, Victor Karpyak, Jennifer
Geske and Mark A. Frye, The
association between sleep disturbances and alcohol relapse: A 12‐month observational
cohort study, The
American Journal on Addictions, 24, 4,
(362-367), (2015).Wiley Online Library
Rishi
Sharma, Pradeep Sahota and Mahesh
M. Thakkar, Role of Adenosine and the Orexinergic Perifornical
Hypothalamus in Sleep-Promoting Effects of Ethanol,
Sleep, 37, 3,
(525), (2014).Crossref
Howard
C. Becker and Patrick J. Mulholland,
Neurochemical mechanisms of alcohol withdrawal, Alcohol
and the Nervous System, 10.1016/B978-0-444-62619-6.00009-4, (133-156),
(2014).Crossref
Howard
C. Becker, Alcohol Dependence, Withdrawal, and Relapse,
Neurobiology of Alcohol Dependence, 10.1016/B978-0-12-405941-2.00019-5, (377-410),
(2014).Crossref
Melissa
A. Riegle, Melissa L. Masicampo, Erin H. Caulder and Dwayne
W. Godwin, Ethosuximide reduces electrographical and behavioral
correlates of alcohol withdrawal seizure in DBA/2J mice,
Alcohol, 48, 5,
(445), (2014).Crossref
Ian
M. Colrain, Christian L. Nicholas and Fiona C. Baker, Alcohol and the sleeping
brain, Alcohol and the Nervous System, 10.1016/B978-0-444-62619-6.00024-0, (415-431),
(2014).Crossref
J.T.
Arnedt and D.A. Conroy, Substance
and Alcohol-Related Disorders and Sleep, Encyclopedia
of Sleep, 10.1016/B978-0-12-378610-4.00481-2, (405-413),
(2013).Crossref
Erik
K. St. Louis, Sleep Disorders and Systemic Disease, Neurological Disorders due to Systemic Disease, (261-281),
(2013).Wiley Online Library
Walter
F. Wiggins, John D. Graef, Tiffany
W. Huitt and Dwayne W. Godwin,
Ethosuximide Reduces Ethanol Withdrawal–Mediated Disruptions in Sleep‐Related
EEG Patterns, Alcoholism:
Clinical and Experimental Research, 37, 3,
(372-382), (2012).Wiley Online Library
Kai
Spiegelhalder, Wolfram Regen, Svetoslava Nanovska, Chiara
Baglioni and Dieter Riemann,
Comorbid Sleep Disorders in Neuropsychiatric Disorders Across the Life Cycle, Current Psychiatry Reports, 15,
6, (2013).Crossref
Péter
Simor, Klára Horváth, Péter
P. Ujma, Ferenc Gombos and Róbert
Bódizs, Fluctuations between sleep and wakefulness: Wake-like
features indicated by increased EEG alpha power during different sleep stages in nightmare
disorder, Biological
Psychology, 94, 3,
(592), (2013).Crossref
Jyotsna
Sahni, Sleep Disturbance, Advancing
Medicine with Food and Nutrients, Second Edition,
10.1201/b13694-37, (549-570), (2013).Crossref
Roseanne
Armitage, Robert Hoffmann, Deirdre
A. Conroy, J. Todd Arnedt and Kirk J. Brower, Effects of a 3-Hour
Sleep Delay on Sleep Homeostasis in Alcohol Dependent Adults,
Sleep, 35, 2,
(273), (2012).Crossref
Leila Tarokh, Eliza
Reen, Christine Acebo, Monique
LeBourgeois, Ronald Seifer, Gahan Fallone and Mary
A. Carskadon, Adolescence and Parental History of Alcoholism:
Insights from the Sleep EEG, Alcoholism:
Clinical and Experimental Research, 36, 9,
(1530-1541), (2012).Wiley Online Library
Bethany
K. Bracken, David M. Penetar, Robert Ross Maclean and Scott
E. Lukas, KudzuRoot Extract Does Not Perturb the Sleep/Wake Cycle
of Moderate Drinkers, The
Journal of Alternative and Complementary Medicine,
17, 10,
(961), (2011).Crossref
Kirk J. Brower, Robert Hoffmann, Deirdre
A. Conroy, J. Todd Arnedt and Roseanne Armitage, Sleep homeostasis
in alcohol-dependent, depressed and healthy control men,
European Archives of Psychiatry and Clinical Neuroscience, 261,
8, (559), (2011).Crossref
Julia
Puetz, Svenja Grohmann, Birgitta
Metternich, Corinna Kloepfer, Bernd Feige, Christoph
Nissen, Dieter Riemann, Michael
Hüll and Magdolna Hornyak,
Impaired memory consolidation during sleep in patients with functional memory
disorder, Biological
Psychology, 86, 1,
(31), (2011).Crossref
Deirdre
A Conroy, Todd J Arnedt and Kirk J Brower, Substance-Induced Insomnia,
Insomnia, 10.3109/9781420080803.016, (165-180), (2010).Crossref
Kirk
J. Brower and Brian E. Perron,
Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive
substances, Medical
Hypotheses, 74, 5,
(928), (2010).Crossref
Markus
Heilig, Mark Egli, John
C. Crabbe and Howard C. Becker,
REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism:
are they linked?, Addiction
Biology, 15, 2,
(169-184), (2010).Wiley Online
Library
Ian M. Colrain, Sharon
Turlington and Fiona C. Baker,
Impact of Alcoholism on Sleep Architecture and EEG Power Spectra in Men and
Women, Sleep, 32,
10, (1341), (2009).Crossref
Megan
E. Kurth, Katherine M. Sharkey, Richard P. Millman, Richard
P. Corso and Michael D. Stein,
Insomnia Among Methadone-Maintained Individuals: The Feasibility of Collecting
Home Polysomnographic Recordings, Journal
of Addictive Diseases, 28, 3,
(219), (2009).Crossref
Kirk
J. Brower, Hyungjin Myra Kim, Stephen Strobbe, Maher
A. Karam‐Hage, Flavia Consens and Robert A. Zucker, A Randomized Double‐Blind
Pilot Trial of Gabapentin Versus Placebo to Treat Alcohol Dependence and Comorbid
Insomnia, Alcoholism:
Clinical and Experimental Research, 32, 8,
(1429-1438), (2008).Wiley Online Library
Rudy
Bowen, Gerald Block and Marilyn
Baetz, Mood and Attention Variability in Women with Alcohol Dependence:
A Preliminary Investigation, The
American Journal on Addictions, 17, 1,
(77-81), (2010).Wiley Online Library
Fabio
Ferrarelli, Richard Smith, Daniela
Dentico, Brady A. Riedner, Corinna
Zennig, Ruth M. Benca, Antoine
Lutz, Richard J. Davidson, Giulio
Tononi and Wieslaw Nowinski,
Experienced Mindfulness Meditators Exhibit Higher Parietal-Occipital EEG Gamma
Activity during NREM Sleep, PLoS
ONE, 10.1371/journal.pone.0073417, 8,
8, (e73417), (2013).Crossref
if (articleRef) { articleRef.style.display = "none"; }
Caption
if(window._satellite) {
_satellite.pageBottom();
}
var _prum=[['id','59e8fecb3847311aab7b23c6'],['mark','firstbyte',(new Date()).getTime()]];(function(){var s=document.getElementsByTagName('script')[0],p=document.createElement('script');p.async='async';p.src='//rum-static.pingdom.net/prum.min.js';s.parentNode.insertBefore(p,s);})();
Clash Royale CLAN TAG
