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Oxidoreductase








Oxidoreductase


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In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. This group of enzymes usually utilizes NADP or NAD+ as cofactors.[1][2] Transmembrane oxidoreductases create electron transport chains in bacteria, chloroplasts and mitochondria, including respiratory complexes I, II and III. Some others can associate with biological membranes as peripheral membrane proteins or be anchored to the membranes through a single transmembrane helix. [3].




Contents






  • 1 Reactions


  • 2 Nomenclature


  • 3 Classification


  • 4 See also


  • 5 References


  • 6 External links





Reactions[edit]


For example, an enzyme that catalyzed this reaction would be an oxidoreductase:


A– + B → A + B–

In this example, A is the reductant (electron donor) and B is the oxidant (electron acceptor).


In biochemical reactions, the redox reactions are sometimes more difficult to see, such as this reaction from glycolysis:


Pi + glyceraldehyde-3-phosphate + NAD+ → NADH + H+ + 1,3-bisphosphoglycerate

In this reaction, NAD+ is the oxidant (electron acceptor), and glyceraldehyde-3-phosphate is the reductant (electron donor).



Nomenclature[edit]


Proper names of oxidoreductases are formed as "donor:acceptor oxidoreductase"; however, other names are much more common. The common name is "donor dehydrogenase" when possible, such as glyceraldehyde-3-phosphate dehydrogenase for the second reaction above. Common names are also sometimes formed as "acceptor reductase", such as NAD+ reductase. "Donor oxidase" is a special case where O2 is the acceptor.



Classification[edit]


Oxidoreductases are classified as EC 1 in the EC number classification of enzymes. Oxidoreductases can be further classified into 22 subclasses:




  • EC 1.1 includes oxidoreductases that act on the CH-OH group of donors (alcohol oxidoreductases)


  • EC 1.2 includes oxidoreductases that act on the aldehyde or oxo group of donors


  • EC 1.3 includes oxidoreductases that act on the CH-CH group of donors (CH-CH oxidoreductases)


  • EC 1.4 includes oxidoreductases that act on the CH-NH2 group of donors (Amino acid oxidoreductases, Monoamine oxidase)


  • EC 1.5 includes oxidoreductases that act on CH-NH group of donors


  • EC 1.6 includes oxidoreductases that act on NADH or NADPH


  • EC 1.7 includes oxidoreductases that act on other nitrogenous compounds as donors


  • EC 1.8 includes oxidoreductases that act on a sulfur group of donors


  • EC 1.9 includes oxidoreductases that act on a heme group of donors


  • EC 1.10 includes oxidoreductases that act on diphenols and related substances as donors


  • EC 1.11 includes oxidoreductases that act on peroxide as an acceptor (peroxidases)


  • EC 1.12 includes oxidoreductases that act on hydrogen as donors


  • EC 1.13 includes oxidoreductases that act on single donors with incorporation of molecular oxygen (oxygenases)


  • EC 1.14 includes oxidoreductases that act on paired donors with incorporation of molecular oxygen


  • EC 1.15 includes oxidoreductases that act on superoxide radicals as acceptors


  • EC 1.16 includes oxidoreductases that oxidize metal ions


  • EC 1.17 includes oxidoreductases that act on CH or CH2 groups


  • EC 1.18 includes oxidoreductases that act on iron-sulfur proteins as donors


  • EC 1.19 includes oxidoreductases that act on reduced flavodoxin as a donor


  • EC 1.20 includes oxidoreductases that act on phosphorus or arsenic in donors


  • EC 1.21 includes oxidoreductases that act on X-H and Y-H to form an X-Y bond


  • EC 1.97 includes other oxidoreductases



See also[edit]



  • Hydroxylase

  • List of enzymes



References[edit]





  1. ^ Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 ed.). Wiley-Interscience. ISBN 0471205036..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  2. ^ Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third ed.). USA: Oxford University Press. ISBN 019850229X.


  3. ^ Superfamilies of single-pass transmembrane oxidoreductases in Membranome database




External links[edit]



  • EC 1 Introduction from the Department of Chemistry at Queen Mary, University of London


























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