FUT4
FUT4
Jump to navigation
Jump to search
| fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) | |
|---|---|
| Identifiers | |
| Symbol | FUT4 |
| Alt. symbols | CD15, FCT3A, ELFT, SSEA-1, LeX |
| Entrez | 2526 |
| HUGO | 4015 |
| OMIM | 104230 |
| RefSeq | NM_002033 |
| UniProt | P22083 |
| Other data | |
| EC number | 2.4.1.152 |
| Locus | Chr. 11 q21 |
Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific), also known as FUT4, is an enzyme which in humans is encoded by the FUT4 gene.[1][2][3]
Function[edit]
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15).[4][5]
References[edit]
^ Goelz SE, Hession C, Goff D, Griffiths B, Tizard R, Newman B, Chi-Rosso G, Lobb R (December 1990). "ELFT: a gene that directs the expression of an ELAM-1 ligand". Cell. 63 (6): 1349–56. doi:10.1016/0092-8674(90)90430-M. PMID 1702034..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
^ Couillin P, Mollicone R, Grisard MC, Gibaud A, Ravisé N, Feingold J, Oriol R (1991). "Chromosome 11q localization of one of the three expected genes for the human alpha-3-fucosyltransferases, by somatic hybridization". Cytogenet. Cell Genet. 56 (2): 108–11. doi:10.1159/000133061. PMID 1672847.
^ Reguigne I, James MR, Richard CW, Mollicone R, Seawright A, Lowe JB, Oriol R, Couillin P (1994). "The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21". Cytogenet. Cell Genet. 66 (2): 104–6. doi:10.1159/000133677. PMID 8287679.
^ "Entrez Gene: FUT4".
^ Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, Nakamura M, Karube M, Sasaki K, Narimatsu H (May 2001). "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV". J. Biol. Chem. 276 (19): 16100–6. doi:10.1074/jbc.M007272200. PMID 11278338.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it. |
Categories:
- Genes on human chromosome 11
- Human chromosome 11 gene stubs
(window.RLQ=window.RLQ||).push(function(){mw.config.set({"wgPageParseReport":{"limitreport":{"cputime":"0.204","walltime":"0.252","ppvisitednodes":{"value":703,"limit":1000000},"ppgeneratednodes":{"value":0,"limit":1500000},"postexpandincludesize":{"value":56438,"limit":2097152},"templateargumentsize":{"value":410,"limit":2097152},"expansiondepth":{"value":7,"limit":40},"expensivefunctioncount":{"value":1,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":14984,"limit":5000000},"entityaccesscount":{"value":1,"limit":400},"timingprofile":["100.00% 194.895 1 -total"," 61.54% 119.934 1 Template:Reflist"," 51.68% 100.715 4 Template:Cite_journal"," 20.17% 39.308 1 Template:Infobox_protein"," 16.99% 33.119 1 Template:Infobox"," 12.13% 23.635 4 Template:Navbox"," 9.91% 19.314 1 Template:Glycosyltransferases"," 5.70% 11.101 1 Template:Gene-11-stub"," 4.83% 9.416 1 Template:Asbox"," 3.84% 7.488 1 Template:Cite_web"]},"scribunto":{"limitreport-timeusage":{"value":"0.109","limit":"10.000"},"limitreport-memusage":{"value":3430843,"limit":52428800}},"cachereport":{"origin":"mw1247","timestamp":"20181024001615","ttl":1900800,"transientcontent":false}}});mw.config.set({"wgBackendResponseTime":349,"wgHostname":"mw1247"});});
Clash Royale CLAN TAG
